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Deceptively Simple NMR Spectra of Contiguously 13C-enriched Compounds

Alex D. Bain ; Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1
Eckardt Wolf ; Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1
Donald W. Hughes ; Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1
Ian D. Spenser ; Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1

Sažetak

Contiguously 13C-enriched compounds are widely used in biosynthetic studies, since they effectively label a bonded pair of carbon atoms, rather than an individual atom. Such compounds are referred to as »bond labeled« compounds. With such substrates, the course of biosynthesis can be followed using 13C-NMR spectroscopy.
When the enriched carbon atoms are chemically but not magnetically equivalent, the 13C-NMR spectra are unusual, and such spectra have been labeled "deceptively simple«. Furthermore, the use of standard NMR experiments such as DEPT (Distortionless Enhancement by Polarization Transfer) is complicated by the presence of homonuclear coupling between 13C nuclei. At natural abundance, the 13C nucleus is magnetically dilute and shows no homonuclear coupling. This paper analyzes the 13C-NMR spectra of a series of molecules derived from fully 13C-enriched acetylene, and explores some of the complications that arise in applying pulse NMR methods.

Ključne riječi

Hrčak ID:

136679

URI

https://hrcak.srce.hr/136679

Datum izdavanja:

3.6.1996.

Posjeta: 933 *