Acta Pharmaceutica, Vol. 54 No. 4, 2004.
Izvorni znanstveni članak
Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery
PARISA YOUNESSI
MOHAMMAD REZA AVADI
KOOROUSH SHAMIMI
ASSAL MIR MOHAMMAD SADEGHI
LEILA MOEZI ELAHEH NAHID
KHOSROW BAYATI
AHMAD REZA DEHPOUR
MORTEZA RAFIEE-TEHRANI
Sažetak
In previous studies, it was established that chitosan and its quaternized derivatives are potent enhancers of hydrophilic compounds absorption across intestinal epithelia. The aim of this study was to evaluate the application of a new quaternized chitosan, triethyl chitosan (TEC), in pharmaceutical approaches. TEC was synthesized by a one step process via a 22 factorial design to optimize the preparation conditions. In ex vivo experiments, everted rat colon sac was used to determine the effect of TEC on the penetration of hydrophilic compounds of different molecular masses (e.g., sodium fluorescein and brilliant blue) through colonic epithelia in comparison with chitosan at pH 7.4. These studies indicated a significant increase in absorption of sodium fluorescein and brilliant blue in the presence of TEC compared to chitosan. TEC bearing positive charge is able to interact with the tight junctions of colon epithelia and hence increase the permeation of sodium fluorescein and brilliant blue through the tight junctions. This investigation has shown that triethyl chitosan could be used as a penetration enhancer for poorly absorbable compounds in the colon drug delivery system.
Ključne riječi
triethyl chitosan; absorption enhancer; colon
Hrčak ID:
16909
URI
Datum izdavanja:
1.12.2004.
Posjeta: 2.215 *