Acta clinica Croatica, Vol. 59. No. 2., 2020.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2020.59.02.07
Independent Factors for Poor Prognosis in Young Patients with Stage I-III Breast Cancer
Ivan Erić
orcid.org/0000-0002-5511-6436
; Josip Juraj Strossmayer University in Osijek, Faculty of Medicine, Osijek, Croatia; Osijek University Hospital Centre, Osijek, Croatia
Anamarija Petek Erić
; Josip Juraj Strossmayer University in Osijek, Faculty of Medicine, Osijek, Croatia; Osijek University Hospital Centre, Osijek, Croatia
Ivan Koprivčić
; Josip Juraj Strossmayer University in Osijek, Faculty of Medicine, Osijek, Croatia; Osijek University Hospital Centre, Osijek, Croatia
Marko Babić
; Josip Juraj Strossmayer University in Osijek, Faculty of Medicine, Osijek, Croatia; Osijek University Hospital Centre, Osijek, Croatia
Stana Pačarić
; Osijek University Hospital Centre, Osijek, Croatia
Bojan Trogrlić
; Josip Juraj Strossmayer University in Osijek, Faculty of Medicine, Osijek, Croatia; Osijek University Hospital Centre, Osijek, Croatia
Sažetak
Breast cancer is the most common malignancy in the population of women under 40 years of age. Young age is an independent factor for poor prognosis. In this research, we tried to establish other factors for poor prognosis in stage I-III breast cancer. The following parameters were observed: tumor size, lymph node status, histologic grade, hormonal receptor status, Ki-67 prognostic index, Her2 neu status, histologic type of the tumor, local recurrence and metastases. Logistic regression was used to evaluate the effect of specific factors on the probability of lethal outcome and development of distant metastases. Our patients showed a predominance of T1 tumor (49.4%), had positive
lymph nodes (62%) and most of them were pN1 (61.2%). Up to one-third of patients had triple negative status. Ki-67 proliferation index was high (25%). Multicentric tumor was detected in 23% of patients. There was no difference in overall survival between the two types of surgical procedures. Patients with pN0 status had better overall survival. Breast cancer in the population of young women has a more aggressive nature. Study results indicated positive lymph node status as an independent factor for poor prognosis of stage I-III breast cancer.
Ključne riječi
Breast cancer; Young women; Multivariate analysis; Independent risk factor
Hrčak ID:
243561
URI
Datum izdavanja:
1.6.2020.
Posjeta: 2.326 *