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Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, Vol. . No. 544 =52-53, 2020.

Izvorni znanstveni članak

Hyperferritinemia and COVID-19?

Ivana Čepelak
Slavica Dodig
Ivana Vučenik

Puni tekst: engleski pdf 276 Kb

str. 18-25

preuzimanja: 531

citiraj

Puni tekst: hrvatski pdf 276 Kb

str. 18-25

preuzimanja: 586

citiraj

Sažetak

It has been repeatedly described that increased serum ferritin concentration or hyperferritinemia is as- sociated with COVID-19, especially with more severe forms of this disease.
Ferritin is a molecule whose concentration is determined as a marker of reflecting the body’s iron supply and less significantly as a marker of inflammation of infectious and non-infectious origin. The expression of this vital molecule for iron metabolism is therefore regulated, primarily by an iron- dependent mechanism. However, in addition to this regulation, there appears to be feedback between ferritin and cytokines in the control of pro-inflammatory and anti-inflammatory mediators.
This review paper includes basic data on ferritin and the potential causes and consequences of hyper- ferritinemia with implications for COVID-19.

Ključne riječi

hyperferritinemia; COVID-19; inflammation; iron metabolism; ferritin

Hrčak ID:

248876

URI

https://hrcak.srce.hr/248876

Datum izdavanja:

15.12.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 4.544 *