Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.04.08

Primary Hyperparathyroidism and Serum Calcium in Breast Cancer Patients Evaluated for Low Bone Mass – A Single Center Experience

Marija Punda orcid.org/0000-0002-4645-9170 ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University of Applied Health Sciences, Zagreb, Croatia
Petra Petranović Ovčariček ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Anita Tabain ; Department of Radiology and Nuclear Medicine, PET/CT Center, Medikol Polyclinic, Zagreb, Croatia
Klaas Pieter Koopmans ; Department of Nuclear Medicine and Radiology, Martini Hospital, Groningen, The Netherlands
Gabriela Alfier ; Department of Surgery, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Tomislav Jukić orcid.org/0000-0001-5631-164X ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ana Fröbe orcid.org/0000-0002-5834-9841 ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia

Sažetak

The bone health guidelines for breast cancer (BC) patients recommend bone mineral
density (BMD) testing. Patients with low BMD and elevated serum calcium levels (SCLs) are
further evaluated for primary hyperparathyroidism (PHPT). We aimed to determine the prevalence
of PHPT in treated BC patients with low BMD and analyze the association of SCLs with histopathologic
tumor features and cancer treatment. This retrospective study included postmenopausal
BC patients examined at Osteoporosis Clinic between 2013 and 2020. Clinical and BMD data were
collected from patient medical records. Patients with biochemical suspicion of PHPT underwent
standard parathyroid imaging procedures. Nine out of 137 (6.6%) patients were diagnosed with
PHPT; 8/9 patients underwent parathyroidectomy and one patient was advised to follow-up. Among
the rest of 128 non-PHPT patients, higher SCLs showed a trend of positive association with higher
tumor grade and axillary lymph node involvement, and received immunotherapy, although without
statistical significance. We found a higher prevalence of PHPT in treated BC patients compared to
the general population. Higher SCLs show a trend of positive correlation with some more aggressive
histopathologic tumor features and with immunotherapy. The results of this study suggest that assessment
of SCLs should be routinely performed to rule out PHPT in treated BC patients with low
BMD.

Ključne riječi

Primary hyperparathyroidism; Serum calcium; Breast cancer; Bone mineral density; Cancer treatment

Hrčak ID:

275453

URI

https://hrcak.srce.hr/275453

Datum izdavanja:

1.12.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.814 *