Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.04.20

Maternal Gut Microbiota in Pregnancies Resulting in Down Syndrome Newborns – a Pilot Study

Mehmet Hursitoglu orcid.org/0000-0002-9062-118X ; Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; Internal Medicine Department, Basaksehir Cam & Sakura Hospital, University of Health Sciences, Istanbul, Turkey
Alev Kural ; Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Sibel Kuras orcid.org/0000-0002-1230-7777 ; Biochemistry Department, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, Turkey
Esra Akdeniz ; Department of Medical Education, Marmara Medical Faculty, Marmara University, Istanbul, Turkey
Salim Sezer ; Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Sema Suzen Caypinar ; Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Cemal Kazezoglu ; Biochemistry Department, Kanuni Sultan Suleyman Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Bulent Yaprak ; Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Faruk Karandere orcid.org/0000-0002-7423-0170 ; Internal Medicine Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Hamit Zafer Guven ; Gynecology and Obstetrics Department, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey

Sažetak

Down syndrome (DS) is one of the main genetic abnormalities of newborns.
Therefore, prenatal diagnosis of this syndrome is of paramount importance to the family and the community.
The microbiota system is important in early brain development. We tried to study and compare
gut microbiota (GM) composition in pregnancies that resulted in DS neonates with pregnancies
that resulted in healthy children. The study population consisted of 21 pregnant women having delivered
DS newborns (group 1) and 22 pregnant women who had given birth to healthy newborns
(group 2). The GM composition was determined and compared between the two groups. There were
no significant age and gestational age differences between the two groups (p>0.005 both). Regarding
GM analysis, microorganisms of the families Clostridiaceae and Pasteurellaceae were more abundant in
the group of women having delivered DS neonates than the group of women having delivered healthy
newborns (p<0.05). The results of our pilot study showed that the GM system might have a role in the
pathophysiology of DS. The GM changes may be used in the prenatal diagnosis and prevention of this
syndrome. Further studies are needed in this field.

Ključne riječi

Brain; Down syndrome; Microbiota; Pregnancy; Outcome; Screening

Hrčak ID:

275517

URI

https://hrcak.srce.hr/275517

Datum izdavanja:

1.12.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.358 *