Izvorni znanstveni članak
Evaluation of the Intraocular Pressure-Reducing Effect of Latanoprost as Monotherapy in Open-Angle Glaucoma
Z. Mandić
L. Bojić
K. Novak-Lauš
D. Šarić
Sažetak
Objective of this study was to evaluate the intraocular pressure-reducing effect of
latanoprost as monotherapy after replacing current dual therapy in glaucoma patients.
The 6-months study comprised 189 patients with primary open angle glaucoma who
were treated at least 6 months with two different kind of topical medications ( -blockers,
pilocarpine, dorzolamide and brimonidine). Due to local side effects, multiple dosing regime
and inadequately controlled intraocular pressure (IOP), they where switched to
latanoprost 0.005% monotherapy. After switched to latanoprost, mean (IOP) was measured
at baseline, after l5 days, 2 and 6 months of treatment. After six-months 178 patients
had completed the study. These analyses enrolled all patients (n=189), thus, the
Intention-To-Treat (ITT) results were shown instead of the results of the reduced population.
IOP was clinically importantly reduced from baseline level. Five patients had
uncontrolled IOP. The difference between IOP before (21.9 2.4) and after 15 days
(17.4 1.7), 2 months (16.7 1.8) and 6 months (16.6 1.4) was statistically significant
(p< 0.001). 90% patients has reached target IOP 18 mm. A conjunctival hyperaemia in
18 (9%), stinging and itching in 7 (4%) patients was reported. Increased iris pigmentation
was seen in 3 (2%) patients. The results of this study indicate that dual therapy in
open-angle glaucoma can effectively be replaced by latanoprost monotherapy in many
patients.
Ključne riječi
Hrčak ID:
28304
URI
Datum izdavanja:
16.12.2002.
Posjeta: 907 *