Izvorni znanstveni članak
Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers
Nada Restek-Samaržija
Maja Blanuša
Alica Pizent
Miroslav Samaržija
Rajka Turk
Naima Čorović
Jasna Jurasović
Sažetak
The aim of this study was to evaluate the efficacy of (DMSA) meso-2,3-dimercaptosuccinic acid treatment in workers with increased lead absorption and no overt symptoms of lead poisoning. Seven occupationally lead exposed male workers with blood lead concentrations (PbB) exceeding 50 µg/100 ml and a positive (EDTA) calcium disodium ethylenediaminetetraacetate lead mobilization test were treated with DMSA for 19 days. Individual doses were 700 mg DMSA, three times a day from day one to five, and twice a day from day six to 19. The treatment intensified urinary lead excretion, most rapidly during the first five days. The increased elimination was followed by a decline of mean PbB to 15% of the pretreatment values. However, 15 days after the treatment, the PbB concentrations rebounded, yet kept below the baseline values and did not exceed 40 µg/100 ml. After repeated EDTA lead mobilization test, urine lead was 23–68% of that before DMSA treatment. It can be concluded that DMSA can effectively reduce chelatable lead in occupationally exposed workers.
Ključne riječi
blood; calcium; CaNa2EDTA; chelation therapy; copper; iron; lead; magnesium; meso-2,3-dimercaptosuccinic acid; mobilisation test; occupational exposed; urine; workers; zinc
Hrčak ID:
3309
URI
Datum izdavanja:
17.12.1998.
Posjeta: 2.627 *