Izvorni znanstveni članak
Short-term ambient air pollution and blood pressure in Croatia: preliminary results from the EH-UH 2 study
Jagoda Nikić
Anamarija Vukšić
Ana Jelaković
Ana Stupin
Iva Abramović
Darija Baković
Mihaela Marinović Glavić
Goran Gajski
Ivana Herceg Bulić
Marija Domislović
Lovorka Bilajac
Andrej Belančić
Josipa Josipović
Željko Reiner
Ivan Pećin
Bojan Jelaković
Sažetak
Introduction: Evidence on short-term ambient air pollution and blood pressure in Croatia is limited, particularly for delayed and non-linear associations. We examined whether short-term ambient air-pollution exposure was associated with office blood pressure (BP) in participants from the Croatian EH-UH 2 study.
Materials and Methods: This cross-sectional environmental epidemiological analysis linked EH-UH 2 blood-pressure and participant-level data with date- and location-specific air-pollution and meteorological data. Daily 24-hour mean concentrations of particulate matter (PM2.5 and PM10), sulfur dioxide (SO2), ozone (O3), nitrogen dioxide (NO2), and nitrogen oxides (NOx) were obtained from CAMS European air quality forecasts. Each pollutant was analyzed in a separate distributed lag non-linear model over lag 0-6 days. The main model was adjusted for age, sex, body mass index, smoking, air temperature, and season.
Results: The primary office systolic BP (SBP) analytic sample included 1528 participants. In the primary model, SO2 was the only pollutant with a positive, statistically significant association with office SBP. The cumulative contrast comparing the 75th with the 25th percentile of SO2 exposure over lag 0-6 days was associated with an 11.7 mmHg higher office SBP (95% CI 4.6 to 18.8; p = 0.001). PM2.5, PM10, and O3 showed positive but non-significant estimates. NO2 and NOx showed inverse associations with office SBP, but these estimates were sensitive to county adjustment. The SO2 association was retained after alternative temperature adjustment, urban/rural adjustment, clinical adjustment, cluster-robust standard errors and additional pollutant adjustment, but was attenuated after adjustment for county and calendar time. Secondary home and combined analyses showed smaller and non-significant SO2 estimates.
Conclusions: In this analysis of EH-UH 2 study data, short-term ambient SO2 exposure was associated with higher office systolic BP, although the finding was sensitive to regional and temporal adjustment. Further studies with improved exposure assessment and careful control of regional differences are needed.
Ključne riječi
air pollution; blood pressure; distributed lag non-linear models; public health
Hrčak ID:
348437
URI
Datum izdavanja:
25.6.2026.
Posjeta: 0 *