Pregledni rad

Aging, stress, and the hippocampus

Dorotea Jelić ; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska

Sažetak

The hippocampus is a structure located deep inside the temporal lobe of the brain mainly responsible for learning and memory, however it is equally significant for other cognitive functions. Given the significant role of the hippocampus, extensive research has been conducted to understand how various internal and external stimuli influence it, and how this affects an individual’s behavior and daily functions. In this paper, two factors will be discussed: stress, the body's natural response to challenging situations and a prevalent issue in modern times, and aging, the natural process that is highly desired to be reversible. Both of these elements play a major role, directly or indirectly, on hippocampal plasticity. In the review, a focus was put on acute and chronic stress as well as normal aging and aging encouraged by Alzheimer’s disease (AD) and mild cognitive impairment (MCI).

Ključne riječi

aging; cortisol; hippocampus; norepinephrine; stress

Hrčak ID:

353438

URI

https://hrcak.srce.hr/353438

Datum izdavanja:

20.12.2025.

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