Izvorni znanstveni članak

Propofol-induced electroencephalographic, electrocardiographic and spirometric changes in goats

Arun K. Madan orcid.org/0000-0001-5791-8558 ; Department of Veterinary Physiology, College of Veterinary and Animal Sciences, GBPUAT, Pantnagar, Udham Singh Nagar, Uttarakhand, India
Jayant P. Korde ; Department of Veterinary Physiology, College of Veterinary and Animal Sciences, GBPUAT, Pantnagar, Udham Singh Nagar, Uttarakhand, India
Arup K. Das ; Department of Veterinary Physiology, College of Veterinary and Animal Sciences, GBPUAT, Pantnagar, Udham Singh Nagar, Uttarakhand, India
Sunil K. Rastogi ; Department of Veterinary Physiology, College of Veterinary and Animal Sciences, GBPUAT, Pantnagar, Udham Singh Nagar, Uttarakhand, India

Sažetak

The effects of Propofol-induced electroencephalographic, electrocardiographic and spirometric changes were studied at a lower dose rate (0.4 mg/kg body mass, intravenously) and at higher dose rate (0.5 mg/kg body mass, intravenously) in four apparently healthy goats 10 to 14 months old, weighing 9 to 12 kg. Electroencephalographic results showed that anesthesia was induced with a change of distorted β wave patterns to α waves within one minute. The α wave patterns continued for 5 to 6 minutes at the lower dose (0.4 mg/kg
body mass) while they persisted for 12 to 13 minutes at the higher dose (0.5 mg/kg body mass). At the lower dose, recovery was predictable after 5 minutes on reversal of the EEG pattern from α to β waves, whereas at the higher dose α wave patterns continued for 15 minutes. The occurrence of the righting reflfl ex was noticed after the disappearance of α waves. The heart rate increased with both the dose rates within the fifi rst 5 minutes and
decreased after 10 and 15 minutes of induction. Inverted T waves were found in two goats at the lower dose while at the higher dose it was found to be inverted in three of the four goats. One of the goats inducted with the higher dose showed tachycardia, with ectopic beats from the 5th to 7th minute post induction. On average, apnea was noticed for the fifi rst 30 seconds at the lower dose and for 42 seconds at the higher dose. One of the animals receiving the higher dose showed apnea for 314 seconds. This goat was given artififi cial respiration after 106 seconds and then again after 296 seconds to resuscitate it. The animal showed severe respiratory distress with abdominal respiration during the fifi rst few seconds. The tidal volume did not return to normal until 15 minutes after induction. This indicates that Propofol has a respiratory depressant activity in goats and positive pressure ventilation must be provided. It does not induce analgesia and should be accompanied by analgesics .

Ključne riječi

propofol; anesthesia; goat; electroencephalography; electrocardiography; respiration

Hrčak ID:

53096

URI

https://hrcak.srce.hr/53096

Datum izdavanja:

8.3.2010.

Podaci na drugim jezicima: hrvatski

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