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Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome

Zlatko Cubranic orcid.org/0000-0002-6989-5100 ; Department of Cardiovascular Medicine, University Hospital Rijeka, Rijeka, Croatia
Zeljko Madzar ; Department of Cardiovascular Medicine, University Hospital Rijeka, Rijeka, Croatia
Sanja Matijevic orcid.org/0000-0003-0627-2114 ; Department of Cardiovascular Medicine, University Hospital Rijeka, Rijeka, Croatia
Stefica Dvornik ; Department of Clinical Laboratory Diagnostics, University Hospital Rijeka, Rijeka, Croatia
Elizabeta Fisic ; Department of Clinical Laboratory Diagnostics, University Hospital Rijeka, Rijeka, Croatia
Vjekoslav Tomulic orcid.org/0000-0002-3749-5559 ; Department of Cardiovascular Medicine, University Hospital Rijeka, Rijeka, Croatia
Juraj Kunisek ; Special Hospital Thalassotherapia Crikvenica, Crikvenica, Croatia
Gordana Laskarin ; Division of Cardiology, Special hospital for medical rehabilitation of the hearth and lung diseases and rheumatism “Thalassotherapia - Opatija”, Opatija, Croatia and Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, C
Igor Kardum ; Department of Psychology, Faculty of Arts and Sciences, University of Rijeka, Rijeka, Croatia
Luka Zaputovic orcid.org/0000-0001-9415-9618 ; Department of Cardiovascular Medicine, University Hospital Rijeka, Rijeka, Croatia

Sažetak

Introduction: This study aimed to assess whether heart fatty acid-binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) could be used for the accurate diagnosis of acute myocardial infarction (AMI) in acute coronary syndrome (ACS) patients.
Materials and methods: The study included 108 ACS patients admitted to a coronary unit within 3 h after chest pain onset. AMI was distinguished from unstable angina (UA) using a classical cardiac troponin I (cTnI) assay. H-FABP and GPBB were measured by ELISA on admission (0 h) and at 3, 6, 12, and 24 h after admission; their accuracy to diagnose AMI was assessed using statistical methods.
Results: From 92 patients with ACS; 71 had AMI. H-FABP and GPBB had higher peak value after 3 h from admission than cTnI (P = 0.001). Both markers normalized at 24 h. The area under the receiver operating characteristic curves was significantly greater for both markers in AMI patients than in UA patients at all time points tested, including admission (P < 0.001). At admission, the H-FABP (37%) and GPBB (40%) sensitivities were relatively low. They increased at 3 and 6 h after admission for both markers and decreased again after 24 h. It was 40% for H-FABP and approximately 2-times lower for GPBB (P < 0.01). In AMI patients, both biomarkers had similar specificities, positive- and negative-predictive values, positive and negative likelihood ratios, and risk ratios for AIM.
Conclusion: H-FABP and GPBB can contribute to early AMI diagnosis and can distinguish AMI from UA.

Ključne riječi

biological markers; heart fatty acid-binding protein; glycogen phosphorylase; sensitivity; specificity; acute myocardial infarction

Hrčak ID:

83227

URI

https://hrcak.srce.hr/83227

Datum izdavanja:

15.6.2012.

Posjeta: 2.147 *