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Nickel - Induced Oral Pemphigus Vulgaris -Like Lesions

Kobkan Thongprasom orcid id orcid.org/0000-0001-7627-919X ; Oral Medicine Department, Faculty of Dentistry Chulalongkorn University, Bangkok 10330, Thailand
Chontavat Suvanpiyasiri ; Dermatology clinic, Samitivej Hospital, Bangkok,Thailand
Adirek S. Wongsa ; Dental Association of Thailand, 71 Ladprao 95 Wangtonglang, Bangkok 10310, Thailand
Anak Iamaroon ; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry Chiang Mai University, Chiang Mai, Thailand 5020, Dermatology unit, Thailand
Wiwat Korkij ; Faculty of Medicine Chulalongkorn University, Bangkok 10330, Thailand
Boonrat Lohwongwatana ; Department of Metallurgical Engineering Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand
Sariya Sinpitaksakul ; Oral Medicine Department Faculty of Dental Medicine Rangsit University, Prathumthani 12000, Thailand
Patamaporn Nakpipat ; Oral Medicine Department, Faculty of Dentistry Chulalongkorn University, Bangkok 10330, Thailand


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Abstract

So far, only a single case of nickel-induced pemphigus has been reported in the literature. We present a case of a 49-year-old male who had experienced a desquamative gingivitis on the anterior mandibular region which was in contact with porcelain crowns and bridges and severe ulcerations on the right and left buccal mucosa. The lesions did not respond to any medications for a year. After removal of those crowns and bridges with the treatment of potent topical steroids, the lesions responded dramatically. The dental alloy used as the core of crowns and bridges was further investigated using metallurgy techniques. The results showed that the dental alloy mainly contained nickel. Histopathologic and direct immunofluorescence evaluations confirmed a diagnosis of pemphigus vulgaris. We concluded that the patient had experienced nickel-induced pemphigus vulgaris-like lesions on the oral mucosa.

Keywords

Mouth Mucosa; Pemphigus vulgaris; Dental Alloys; Nickel

Hrčak ID:

71733

URI

https://hrcak.srce.hr/71733

Publication date:

23.9.2011.

Article data in other languages: croatian

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