Croatica Chemica Acta, Vol. 77 No. 1-2, 2004.
Izvorni znanstveni članak
C-Acylation of 2-Methylfuran and Thiophene using N-Acylbenzotriazoles
Alan R. Katritzky
; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Kazuyuki Suzuki
; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Sandeep K. Singh
; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Sažetak
Reactions of 2-methylfuran and thiophene with readily available N-acylbenzotriazoles (RCOBt, where R = 4-tolyl, 4-methoxyphenyl, benzyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-pyridyl and 1-naphthyl) in the presence of TiCl4 or ZnBr2 produced 2-methyl-4-acylfurans 2a-e and 2-acylthiophenes 3a-f in average yields of 54 % and 75 %, respectively. Literature yields for the preparation of the same compounds are significantly lower.
Ključne riječi
C-acylation; 2-methylfuran; thiophene; N-acylbenzotriazoles
Hrčak ID:
102662
URI
Datum izdavanja:
31.5.2004.
Posjeta: 2.197 *