Croatica Chemica Acta, Vol. 63 No. 3, 1990.
Izlaganje sa skupa
A Domain Approach to the Adsorption of Complex Proteins: Preliminary Analysis and Application to Albumin
Joseph D. Andrade
; Department of Bioengineering, Center for Biopolymers at Interfaces, University of Utah, 2480 MEB, Salt Lake City, Utah 84112 USA
Vladimir Hlady
; Department of Bioengineering, Center for Biopolymers at Interfaces, University of Utah, 2480 MEB, Salt Lake City, Utah 84112 USA
Ai-Ping Wei
; Department of Bioengineering, Center for Biopolymers at Interfaces, University of Utah, 2480 MEB, Salt Lake City, Utah 84112 USA
Carl-Gustav Golander
; Department of Bioengineering, Center for Biopolymers at Interfaces, University of Utah, 2480 MEB, Salt Lake City, Utah 84112 USA
Sažetak
Albumin consists of three large domains with differences in electrostatic nature, charge-pH characteristics, and denaturability.
The interfacial activity of albumin is due, at least in part, to the mterfacial activity of its constituent domains. Consideration of the structure and interfacial activity of the various domains permits new and more precise hypotheses to be developed, with which new and better experiments can be designed. Such hypotheses allow one to evaluate and compare adsorption data, including kinetics and isotherms, adsorbed layer thickness, refractive index, lateral cohesion, multilayer formation, etc.
We feel strongly that each different protein is a unique molecular personality, which must be understood and considered if we are to more fully understand and apply the interfacial behavior of complex proteins.
Ključne riječi
Hrčak ID:
137389
URI
Datum izdavanja:
28.12.1990.
Posjeta: 909 *