Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.287
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes
Igor Nikolić
; Department of Thoracic Surgery Clinical Hospital “Dubrava,” ZagrebCroatia
Suzana Kukulj
; Clinic for Lung Diseases “Jordanovac,” University HospitalCentre Zagreb, Zagreb, Croatia
Miroslav Samaržija
; Clinic for Lung Diseases “Jordanovac,” University HospitalCentre Zagreb, Zagreb, Croatia
Vjekoslav Jeleč
; Department of Neurosurgery Clinical Hospital “Dubrava,” Zagreb,Croatia
Marko Žarak
orcid.org/0000-0001-6768-9218
; Clinical Department for Laboratory Diagnostics, Clinical Hospital “Dubrava,” Zagreb, Croatia
Biserka Orehovec
; Clinical Department for Laboratory Diagnostics, Clinical Hospital “Dubrava,” Zagreb, Croatia
Ida Taradi
; Clinical Department for Laboratory Diagnostics, Clinical Hospital “Dubrava,” Zagreb, Croatia
Dominik Romić
; Department of Neurosurgery Clinical Hospital “Dubrava,” Zagreb,Croatia
Toni Kolak
; Clinic for Surgery, Clinical Hospital “Dubrava,” Zagreb, Croatia
Leonardo Patrlj
; Clinic for Surgery, Clinical Hospital “Dubrava,” Zagreb, Croatia
Sažetak
Aim To assess the diagnostic value of neutrophil-to-lymphocyte
ratio (NLR) and platelet-to-lymphocyte ratio (PLR)
in lung cancer (LC). We compared the ratios between
healthy participants and all LC patients, as well patients
with different pathohistological LC subtypes.
Methods We retrieved the data on neutrophil, lymphocyte,
and platelet levels in 449 patients with different
pathohistological LC subtypes (non-small cell LC, smallcell
LC, atypical or metastatic LC, neuroendocrine, and
sarcomatoid carcinoma) and 47 healthy controls. NLR and
PLR were calculated by dividing the absolute number of
neutrophils or platelets with the absolute number of lymphocytes.
Results There were significant differences in both NLR
and PLR (P < 0.001) between all LC patients and the control
group, but there were no differences between patients
with different LC subtypes. Reciever operating characteristics
analysis for NLR showed the optimal cut-off value of
2.71, with a sensitivity of 77.05% and specificity of 87.23%.
The optimal cut-off value for PLR was 182.31, with a sensitivity
of 51.09% and specificity of 91.49%.
Conclusion The results showed that the NLR and PLR may
have added value in the early diagnosis of LC, but further
research is needed to confirm these results.
Ključne riječi
Hrčak ID:
170170
URI
Datum izdavanja:
15.6.2016.
Posjeta: 1.379 *