Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.321
Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review
Andrea Gelemanović
; School of Medicine, University of Split, Split, Croatia
Katie Dobberpuhl
; Medical student, Medical College of Wisconsin, Milwaukee, WI, USA
Goran Krakar
; Children’s Hospital Zagreb, Zagreb, Croatia
Inga Patarčić
; School of Medicine, University of Split, Split, Croatia
Ivana Kolčić
orcid.org/0000-0001-7918-6052
; School of Medicine, University of Split, Split, Croatia
Ozren Polašek
orcid.org/0000-0002-5765-1862
; School of Medicine, University of Split, Split, Croatia
Sažetak
Aim To summarize available evidence on the role of host
genetics in the susceptibility to congenital and childhood
cytomegalovirus (CMV) infections by conducting a systematic
review of published studies.
Methods We searched online databases (PubMed, Web of
Science, Scopus and HuGe Navigator) for relevant studies
with well-defined inclusion and exclusion criteria and assessed
the risk of bias using novel Confounding-Selection-
Information bias score (CSI).
Results 5105 studies were initially identified, but only 5
met all the inclusion criteria and were analyzed in detail.
Polymorphisms of the toll-like receptors (TLRs) and mannose-
binding lectin (MBL) genes were shown to have an
impact on the CMV infection in infants. Polymorphisms
of the TLR2 (rs3804100, rs1898830), TLR4 (rs4986791), and
TLR9 (rs352140) were shown to have a role in congenital
CMV infection. Low MBL levels were associated with CMV
infection in Chinese individuals, a finding that was not replicated
in Caucasians. The overall credibility of evidence
was weak.
Conclusions Based on currently available very limited
amount of evidence, it is uncertain whether congenital
and childhood CMV infections are under host genetic control.
Additional primary studies are needed with more specific
research hypotheses that will enable gradual understanding
of specific mechanisms of the CMV pathogenesis.
More genetic studies in the future will facilitate better understanding
of host susceptibility and likely enable novel
preventative and curative measures
Ključne riječi
Hrčak ID:
170174
URI
Datum izdavanja:
15.8.2016.
Posjeta: 1.332 *