Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2017.58.96
Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility
Judit Hajagos-Tóth
; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Eszter Ducza
; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Reza Samavati
; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Sandor G. Vari
; International Research and Innovation in Medicine Program Cedars - Sinai Medical Center, Los Angeles, CA, USA
Robert Gaspar
orcid.org/0000-0002-1571-7579
; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Sažetak
Obesity is a global health problem even among pregnant
women. Obesity alters quality of labor, such as preterm labor,
prolonged labor, and higher oxytocin requirements
in pregnant women. The most important factors to play
a role in the altered gestational period and serve as drug
targets to treat the consequences are female sexual hormones,
calcium channels, adrenergic system, oxytocin,
and prostaglandins. However, we have limited information
about the impact of obesity on the pregnant uterine contractility
and gestation time. Adipose tissue, which is the
largest endocrine and paracrine organ, especially in obesity,
is responsible for the production of adipokines and various
cytokines and chemokines, and there are no reliable
data available describing the relation between body mass
index, glucose intolerance, and adipokines during pregnancy.
Recent data suggest that the dysregulation of leptin,
adiponectin, and kisspeptin during pregnancy contributes
to gestational diabetes mellitus and pre-eclampsia. A
preclinical method for obese pregnancy should be developed
to clarify the action of adipokines and assess their impact
in obesity. The deeper understanding of the adipokines-
induced processes in obese pregnancy may be a step
closer to the prevention and therapy of preterm delivery
or prolonged pregnancy. Gestational weight gain is one of
the factors that could influence the prenatal development,
birth weight, and adiposity of newborn.
Ključne riječi
Hrčak ID:
181569
URI
Datum izdavanja:
15.4.2017.
Posjeta: 1.898 *