Pregledni rad

https://doi.org/10.26800/LV-141-7-8-28

Morphology of myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

Biljana Jelić Puškarić ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Gordana Kaić ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Marina Pažur ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Mia Šunjić Stakor ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Suzana Katalenić Simon ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Inga Mandac Rogulj ; Zavod za hematologiju, Klinika za unutarnje bolesti, KB Merkur, Zagreb
Slobodanka Ostojić Kolonić ; Zavod za hematologiju, Klinika za unutarnje bolesti, KB Merkur, Zagreb;Medicinski fakultet Sveučilišta u Zagrebu, Zagreb
Delfa Radić Krišto ; Zavod za hematologiju, Klinika za unutarnje bolesti, KB Merkur, Zagreb;Medicinski fakultet Sveučilišta u Osijeku, Osijek
Ika Kardum-Skelin ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb

Sažetak

Diagnostic category of MDS/MPN includes clonal hematopoietic neoplasms, which show the concomitant clinical, laboratory and/or morphologic features of both myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN) at the time of diagnosis. Cytopenia and dysplasia of one or more myeloid lineages (the MDS features) can be present accompanied with leukocytosis, thrombocytosis and/or organomegaly (all features more often related to MPN). Patients with a previous diagnosis of MPN who develop the myelodysplastic alterations secondary to disease evolution or chemotherapy are not assigned to this diagnostic category. According to the WHO (World Health Organization) classification from 2008 and the 2016 revision, the MDS/MPN category includes five entities as follows: CMML (chronic myelomonocytic leukemia), JMML (juvenile myelomonocytic leukemia), aCML (atypical chronic myeloid leukemia) BCR-ABL1- , MDS/MPN-RS-T (MDS/MPN with ring sideroblasts and thrombocytosis) and MDS/MPN-U (MDS/MPN, unclassifiable).

Ključne riječi

MYELODYSPLATIC-MYELOPROLIFERATIVE DISEASES – classification, diagnosis, pathology; LEUKEMIA, MYELOMONOCYTIC, CHRONIC – diagnosis, pathology; LEUKEMIA, MYELOMONOCYTIC, JUVENILE – diagnosis, pathology; LEUKEMIA, MYELOID, CHRONIC, ATYPICAL, BCR-ABL NEGATIVE – diagnosis, pathology; THROMBOCITOSIS; ANEMIA, SIDEROBLASTIC

Hrčak ID:

225765

URI

https://hrcak.srce.hr/225765

Datum izdavanja:

27.9.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 6.196 *