Sažetak sa skupa

https://doi.org/10.15836/ccar2019.220

Higher S2PLIT-UG scores at index admission are associated with a higher functional disease burden and increased biomarkers of myocardial injury and ventricular overload among patients with acutely decompensated heart failure

Josip Anđelo Borovac orcid.org/0000-0002-4878-8146 ; Institute of Emergency Medicine of Split-Dalmatia County, Split, Croatia; University of Split School of Medicine, Split, Croatia; University Hospital Centre Split, Split, Croatia
Joško Božić ; University of Split School of Medicine, Split, Croatia
Duška Glavaš ; University of Split School of Medicine, Split, Croatia; University Hospital Centre Split, Split, Croatia

Sažetak

Goals: Outcomes following acutely decompensated heart failure (ADHF) are poor and associated with
increased mortality and morbidity. Various risk stratification systems have been developed in the past
to predict mortality and rehospitalizations in this population. The S2PLiT-UG score was recently introduced
to stratify ADHF patients in three risk categories in respect to all-cause mortality during
1-year post-discharge period.1 I n t his w ork, w e a imed to d etermine a ssociations o f S 2PLiT-UG score
with functional disease burden estimated by NYHA class and biomarkers including high sensitivity
cardiac troponin I (hs-cTnI), NT-proBNP and C-reactive protein (CRP).
Patients and Methods: A cohort of 106 consecutive ADHF patients enrolled at the Cardiology Department
during 2018-2019 were included in the study. S2PLiT-UG score calculation and laboratory analyses
were performed for each patient at index admission.
Results: Fifty-six (52.8%) patients were designated as low, 24 (22.6%) as intermediate, and 26 (24.6%) as
high risk according to S2PLiT-UG score stratification. Patients significantly differed (p=0.021) in respect
to their NYHA class with mean values of 2.85±0.57, 3.10±0.61, and 3.33±0.56 for low, intermediate, and
high-risk group, respectively. Troponin values were significantly higher in high risk compared to intermediate
and low-risk groups (148.4±72 vs. 68.2±48 vs. 42.2±24 ng/L; p=0.025, respectively). Similarly,
NT-proBNP levels were highest in the high-risk group (13740±7884 pg/mL) followed by intermediate
(7811±5668 pg/mL) and low-risk group (4195±1632 pg/mL), p=0.002. Finally, CRP values differed across
groups with the high-risk group exhibiting highest CRP value (21.8±14.8 mg/L) compared to intermediate
and low-risk group (17.5±15.8 and 12.2±11.3 mg/L, respectively), however, this result was not significant
(p=0.327). S2PLiT-UG score positively correlated with NYHA class (r=0.300, p=0.004), hs-cTnI
(r=0.303, p=0.009), NT-proBNP (r=0.353, p=0.001) and CRP (r=0.203, p=0.069).
Conclusion: Among ADHF patients, higher S2PLiT-UG score values, calculated at index admission, are
associated with higher functional disease burden and increased levels of circulating biomarkers reflecting
myocardial injury and ventricular overload, but not systemic inflammation.

Ključne riječi

heart failure; risk score; stratification; natriuretic peptides; troponin

Hrčak ID:

226690

URI

https://hrcak.srce.hr/226690

Datum izdavanja:

15.10.2019.

Posjeta: 1.121 *