Acta Pharmaceutica, Vol. 58 No. 2, 2008.
Izvorni znanstveni članak
https://doi.org/10.2478/v1007-008-0005-4
Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives
HANAA M. HOSNI
; Pesticide Chemistry Department, National Research Centre, Doki, Cairo, Egypt
MOHAMED M. ABDULLA
; Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt
Sažetak
In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6-(2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.
Ključne riječi
pyridinedicarbonitrile; benzopyranopyridine; anti-inflammatrory; analgesic agents
Hrčak ID:
21366
URI
Datum izdavanja:
1.6.2008.
Posjeta: 2.933 *