Croatica Chemica Acta, Vol. 31 No. 2, 1959.
Izvorni znanstveni članak
The Synthesis of Some Optically Active 5,6-Dihydrouracils
D. Keglević
; Tracer Laboratory, Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia
A. Kornhauser
; Tracer Laboratory, Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia
Sažetak
From L-B-amino-d-methyl-hexanoic acid (L-B-homoleucine, la) some in 6-position optically active 5,6-dihydrouracils (IVa-e) were prepared via the corresponding B-ureido esters (IIIa-e). Several methods were tried and the preferable conditions for the retention of optical activity studied. By two ways it was shown that no loss of optical activity during reaction stages I-IV occured: a) alkaline hydrolysis performed on IVa-c gave B-ureido acids (Va-e) which could be converted in dihydrouracils having the same optical .activity; b) acid hydrolysis of !Ia yielded the optically unchanged B-homoleucine (la).
Ključne riječi
Hrčak ID:
245256
URI
Datum izdavanja:
24.9.1959.
Posjeta: 508 *