Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2020.61.126
Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart
Tomo Svaguša
; Department of Cardiovascular Diseases, University of ZagrebSchool of Medicine, Clinical Hospital Dubrava, Zagreb, Croatia
Mislav Martinić
; University of Zagreb School of Medicine, Zagreb, Croatia
Matea Martinić
; University of Zagreb School of Medicine, Zagreb, Croatia
Lucija Kovačević
; Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, Zagreb, Croatia
Ana Šepac
; Department of Pathology, University of Zagreb School of Medicine, Zagreb, Croatia
Davor Miličić
; Department of Cardiovascular Diseases, University of ZagrebSchool of Medicine, University Croatia Hospital Center Zagreb, Zagreb,
Joško Bulum
; Department of Cardiovascular Diseases, University of ZagrebSchool of Medicine, University Croatia Hospital Center Zagreb, Zagreb,
Boris Starčević
; Department of Cardiovascular Diseases, University of ZagrebSchool of Medicine, Clinical Hospital Dubrava, Zagreb, Croatia
Maja Sirotković-Skerlev
; Department of Pathophysiology, University of Zagreb School of Medicine, Zagreb, Croatia
Fran Seiwerth
; Department for Respiratory Diseases Jordanovac, University of Zagreb School of Medicine,University Hospital Centre Zagreb, Zagreb, Croatia
Ana Kulić
; Department of Oncology,Division of Pathophysiology and Experimental Oncology, University Hospital Center Zagreb, Zagreb, Croatia
Filip Sedlić
orcid.org/0000-0002-3733-5985
; Department of Pathophysiology, University of Zagreb School of Medicine, Zagreb, Croatia
Sažetak
Mitochondria are involved in crucial homeostatic process-
es in the cell: the production of adenosine triphosphate
and reactive oxygen species, and the release of pro-apop-
totic molecules. Thus, cell survival depends on the mainte-
nance of proper mitochondrial function by mitochondrial
quality control. The most important mitochondrial quality
control mechanisms are mitochondrial unfolded protein
response, mitophagy, biogenesis, and fusion-fission dy-
namics. This review deals with mitochondrial quality con-
trol in heart diseases, especially myocardial infarction and
heart failure. Some previous studies have demonstrated
that the activation of mitochondrial quality control mech-
anisms may be beneficial for the heart, while others have
shown that it may lead to heart damage. Our aim was to
describe the mechanisms by which mitochondrial quality
control contributes to heart protection or damage and to
provide evidence that may resolve the seemingly contra-
dictory results from the previous studies.
Ključne riječi
Hrčak ID:
253152
URI
Datum izdavanja:
14.6.2020.
Posjeta: 1.009 *