Izvorni znanstveni članak
Symptomatic Epilepsy Associated With Intracranial Calcifications in Children With Acute Lymphoblastic Leukemia (ALL)
N. Barišić
E. Bilić
J. Konja
Sažetak
Acute and long-term sequels of central nervous system (CNS) prophylaxis with irradiation
and intrathecal chemotherapy in children suffering from acute lymphoblastic
leukemia (ALL) include vasculopathies, leucoencephalopathies, intracranial calcifications,
intellectual and neurological impairment.We report two children at the age 5 and 8
years who manifested partial motor or complex seizures and intracranial calcifications
2–4 years after the diagnosis of ALL had been established. The occurrence of these disorders
was much earlier than reported in the literature. Both children received prophylactic
CNS treatment with irradiation and intrathecal methotrexate (MTX). Their brain
CT scans and EEG had been normal before the first epileptic seizure was registered.
Children are now seizure free on carbamazepine, and a boy with complex partial and
myoclonic seizures is also on valproate and vigabatrine. Symptomatic epilepsy associated
with intracranial calcifications and persisting EEG changes might occur as side
effects of ALL treatment.
Ključne riječi
Hrčak ID:
28302
URI
Datum izdavanja:
16.12.2002.
Posjeta: 1.289 *