Veterinarski arhiv, Vol. 94 No. 1, 2024.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.2025
Hesperidin alleviates inflammation in the metabolic syndrome model
Filiz Kazak
; Department of Biochemistry, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
*
Gul Fatma Yarim
; Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
Elvan Anadol
; Laboratory Animals Breeding and Experimental Research Center, Gazi University, Ankara, Turkey
Ayris Salt
; Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey
* Dopisni autor.
Sažetak
In metabolic syndrome, activated inflammatory signaling pathways trigger the release of proinflammatory cytokines. Nowadays, the use of natural bioactive compounds is trending as an alternative method for the treatment and management of metabolic syndrome. This study aimed to assess the potential effects of hesperidin in the metabolic syndrome model by analyzing the proinflammatory and anti-inflammatory cytokines in serum and liver. Rats were divided into 4 groups: Control (Rats were fed a standard chow diet and water ad libitum), hesperidin [Rats were fed hesperidin supplemented standard chow diet (1%, 10 g/kg feed) and water ad libitum] metabolic syndrome (Rats were fed standard chow diet with 10% fructose-added-drinking-water), and metabolic syndrome + hesperidin (Rats were fed a hesperidin-added standard chow diet (1%, 10 g/kg) with 10% fructose-added-drinking-water). Rats were sacrificed under ketamine/xylazine anesthesia, blood was obtained and liver tissues were removed. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-10, and transforming growth factor-beta in the serum and liver were measured by enzyme-linked immunosorbent assay. In the metabolic syndrome group, higher tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6, but lower serum and liver interleukin-10 and transforming growth factor-beta were found in the serum and liver compared to the control group. In addition, in the metabolic syndrome + hesperidin group lower interleukin-1 beta and interleukin-6 but higher serum interleukin-10 and transforming growth factor-beta were found in the serum and liver compared to the metabolic syndrome groups. Consequently, hesperidin suppressed the serum and liver proinflammatory cytokine response and stimulated the anti-inflammatory cytokine response in the metabolic syndrome rat model.
Ključne riječi
cytokine; hesperidin; insulin resistance syndrome; liver; rat
Hrčak ID:
315803
URI
Datum izdavanja:
9.2.2024.
Posjeta: 639 *