Acta clinica Croatica, Vol. 63. No. 1, 2024.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.01.5
Increased renal resistive index as a marker of early stage of diabetic nephropathy in normoalbuminuric children with type 1 diabetes mellitus
Ivana Trutin
; Sestre milosrdnice University Hospital Center, Zagreb, Croatia
*
Gordana Stipančić
; Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Matej Šapina
; Osijek University Hospital Center, Osijek, Croatia; School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; School of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Lea Oletić
; Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mario Laganović
; School of Medicine, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia
* Dopisni autor.
Sažetak
This study aimed to compare the renal resistive index (RI) as an early marker of
renal damage between normoalbuminuric children with type 1 diabetes mellitus (T1D) and normal
age-matched controls. A total of 76 children with T1D (aged 10-18 years) and 76 healthy age-matched
controls were enrolled. Anthropometric parameters, blood pressure, glycated hemoglobin
(HbA1c), serum creatinine (sCr), estimated glomerular fi ltration rate (eGFR), serum uric acid (SUA),
urine albumin/creatinine ratio (ACR), and degree of pubertal development were determined in all
participants. RI was measured using Doppler ultrasound in both groups. The T1D group had lower sCr
and SUA values and higher ACR and mean RI values than the control group. Using the expectation-maximization
method, 2 clusters of T1D patients were identified. Cluster 2 with higher RI values,
eGFR and HDL cholesterol was more prone to albuminuria and could carry worse prognosis. In
conclusion, renal RI is increased in the hyperfiltration phase of diabetic nephropathy in children
with T1D. Renal RI could be helpful as a marker for diagnosing diabetic nephropathy in the early
preclinical course of the disease in normoalbuminuric children with T1D.
Ključne riječi
Doppler renal resistive index; Type 1 diabetes mellitus; Children
Hrčak ID:
322012
URI
Datum izdavanja:
1.4.2024.
Posjeta: 43 *