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Collegium antropologicum, Vol. 35 No. 2, 2011.

Izvorni znanstveni članak

Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies

Bernarda Lozić
Dragan Primorac
Robert Glavinić
Radenka Kuzmanić Šamija
Tatijana Zemunik

Puni tekst: engleski, pdf (60 KB) str. 385-388 preuzimanja: 237* citiraj
APA 6th Edition
Lozić, B., Primorac, D., Glavinić, R., Kuzmanić Šamija, R. i Zemunik, T. (2011). Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies. Collegium antropologicum, 35 (2), 385-388. Preuzeto s https://hrcak.srce.hr/68949
MLA 8th Edition
Lozić, Bernarda, et al. "Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies." Collegium antropologicum, vol. 35, br. 2, 2011, str. 385-388. https://hrcak.srce.hr/68949. Citirano 24.04.2019.
Chicago 17th Edition
Lozić, Bernarda, Dragan Primorac, Robert Glavinić, Radenka Kuzmanić Šamija i Tatijana Zemunik. "Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies." Collegium antropologicum 35, br. 2 (2011): 385-388. https://hrcak.srce.hr/68949
Harvard
Lozić, B., et al. (2011). 'Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies', Collegium antropologicum, 35(2), str. 385-388. Preuzeto s: https://hrcak.srce.hr/68949 (Datum pristupa: 24.04.2019.)
Vancouver
Lozić B, Primorac D, Glavinić R, Kuzmanić Šamija R, Zemunik T. Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies. Collegium antropologicum [Internet]. 2011 [pristupljeno 24.04.2019.];35(2):385-388. Dostupno na: https://hrcak.srce.hr/68949
IEEE
B. Lozić, D. Primorac, R. Glavinić, R. Kuzmanić Šamija i T. Zemunik, "Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies", Collegium antropologicum, vol.35, br. 2, str. 385-388, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/68949. [Citirano: 24.04.2019.]

Sažetak
In this study we analyzed the effect of polymorphic variation of NAD(P)H: quinone oxidoreductase1 (NQO1) gene that
encode enzyme which detoxifies harmful quinines and protect hematopoietic stem cells against oxidative stress. C609T
polymorphism of NQO1 gene leads to loss of enzyme activity, which may be a risk factor in the etiology of specific types of
hematopoietic malignancies.We analyzed C609T polymorphism in NQO1 gene in the group of 82 patients (56 adult and
26 children) with different type of hematopoietic malignancies and 99 healthy participants (61 adult and 38 children)
using PCR and the RFLP method. We confirmed that the polymorphism C609T in NQO1 gene was more frequent in the
adult patients’ group with myeloid disorders, (p=0.0267) compared with adult controls.We could not confirm the association
C609T polymorphism with recurrent chromosome translocations (clonal karyotype changes) neither in the adult
nor in pediatric group of patients.

Ključne riječi
hematological malignancies; polymorphism; NQO1; clonal chromosomal abnormalities

Hrčak ID: 68949

URI
https://hrcak.srce.hr/68949

Posjeta: 392 *