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https://doi.org/10.2478/10004-1254-62-2011-2122

Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro

Ksenija Durgo ; Faculty of Food Technology and Biotechnology, Zagreb, Croatia
Ivana Halec ; Faculty of Food Technology and Biotechnology, Zagreb, Croatia
Ivana Šola ; Faculty of Natural Sciences, Zagreb, Croatia
Jasna Franekić ; Faculty of Food Technology and Biotechnology, Zagreb, Croatia

Puni tekst: engleski, pdf (132 KB) str. 221-226 preuzimanja: 1.025* citiraj
APA 6th Edition
Durgo, K., Halec, I., Šola, I. i Franekić, J. (2011). Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro. Arhiv za higijenu rada i toksikologiju, 62 (3), 221-226. https://doi.org/10.2478/10004-1254-62-2011-2122
MLA 8th Edition
Durgo, Ksenija, et al. "Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro." Arhiv za higijenu rada i toksikologiju, vol. 62, br. 3, 2011, str. 221-226. https://doi.org/10.2478/10004-1254-62-2011-2122. Citirano 18.06.2019.
Chicago 17th Edition
Durgo, Ksenija, Ivana Halec, Ivana Šola i Jasna Franekić. "Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro." Arhiv za higijenu rada i toksikologiju 62, br. 3 (2011): 221-226. https://doi.org/10.2478/10004-1254-62-2011-2122
Harvard
Durgo, K., et al. (2011). 'Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro', Arhiv za higijenu rada i toksikologiju, 62(3), str. 221-226. doi: https://doi.org/10.2478/10004-1254-62-2011-2122
Vancouver
Durgo K, Halec I, Šola I, Franekić J. Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro. Arh Hig Rada Toksikol. [Internet]. 2011 [pristupljeno 18.06.2019.];62(3):221-226. doi: https://doi.org/10.2478/10004-1254-62-2011-2122
IEEE
K. Durgo, I. Halec, I. Šola i J. Franekić, "Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro", Arhiv za higijenu rada i toksikologiju, vol.62, br. 3, str. 221-226, 2011. [Online]. doi: https://doi.org/10.2478/10004-1254-62-2011-2122

Sažetak
Quercetin is the main fl avonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases. Due to its specifi c planar chemical structure, quercetin readily forms chelates with metalions. Complexes of bioactive compounds and metal ions such as lanthanum often show strong
cytotoxic and antitumour properties. The aim of this study was to compare the genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells with compare it to the effects of free ligands, quercetin, and lanthanum alone. The quercetin/lanthanum complex showed considerable cytotoxicity in the concentration range of (100 to 1000) mmol mL-1 and exposure time of three hours. The complex also induced a dose-dependent pro-oxidative effects and the formation of single-strand and double-strand DNA breaks. Although we obtained promising results on the cell level, future experiments should answer whether the quercetin/lanthanum complex is cancer-specific and stable enough in
physiological conditions to make a potential new antitumour drug.

Ključne riječi
chelates; DNA damage; flavonoid/metal complexes, oxidative damag

Hrčak ID: 71765

URI
https://hrcak.srce.hr/71765

[hrvatski]

Posjeta: 1.367 *