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https://doi.org/10.5562/cca1827

Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

Rosana Ribić ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Lidija Habjanec ; Institute of Immunology Inc., Rockefellerova 10, HR-10000 Zagreb, Croatia
Branka Vranešić ; Institute of Immunology Inc., Rockefellerova 10, HR-10000 Zagreb, Croatia
Ruža Frkanec ; Institute of Immunology Inc., Rockefellerova 10, HR-10000 Zagreb, Croatia
Srđanka Tomić ; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (3 MB) str. 233-244 preuzimanja: 699* citiraj
APA 6th Edition
Ribić, R., Habjanec, L., Vranešić, B., Frkanec, R. i Tomić, S. (2011). Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides. Croatica Chemica Acta, 84 (2), 233-244. https://doi.org/10.5562/cca1827
MLA 8th Edition
Ribić, Rosana, et al. "Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides." Croatica Chemica Acta, vol. 84, br. 2, 2011, str. 233-244. https://doi.org/10.5562/cca1827. Citirano 17.11.2019.
Chicago 17th Edition
Ribić, Rosana, Lidija Habjanec, Branka Vranešić, Ruža Frkanec i Srđanka Tomić. "Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides." Croatica Chemica Acta 84, br. 2 (2011): 233-244. https://doi.org/10.5562/cca1827
Harvard
Ribić, R., et al. (2011). 'Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides', Croatica Chemica Acta, 84(2), str. 233-244. https://doi.org/10.5562/cca1827
Vancouver
Ribić R, Habjanec L, Vranešić B, Frkanec R, Tomić S. Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 17.11.2019.];84(2):233-244. https://doi.org/10.5562/cca1827
IEEE
R. Ribić, L. Habjanec, B. Vranešić, R. Frkanec i S. Tomić, "Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides", Croatica Chemica Acta, vol.84, br. 2, str. 233-244, 2011. [Online]. https://doi.org/10.5562/cca1827

Sažetak
A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man-
OCH2CH(CH3)CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory
properties investigated in some preliminary tests in vivo. All newly synthesized glycopeptides
comprise in their structure the adamantylglycyl moiety linked to the dipeptide L-Ala-D-isoGln, as well as
mannose. Adjuvant activity of mannosylated adamant-2-yl tripeptides was tested in the mouse model using
ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-
(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala). (doi: 10.5562/cca1827)

Ključne riječi
O-mannopyranosides; adamantyltripeptides; peptidoglycan monomer; immunomodulation

Hrčak ID: 71986

URI
https://hrcak.srce.hr/71986

Posjeta: 970 *