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https://doi.org/10.5562/cca1817

Neurochemical and Behavioural Changes in Rat Models of Depression

Ivan Skelin ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada
Tomislav Kovačević ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia
Mirko Diksic   ORCID icon orcid.org/0000-0001-8070-6051 ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

Puni tekst: engleski, pdf (1 MB) str. 287-299 preuzimanja: 1.469* citiraj
APA 6th Edition
Skelin, I., Kovačević, T. i Diksic, M. (2011). Neurochemical and Behavioural Changes in Rat Models of Depression. Croatica Chemica Acta, 84 (2), 287-299. https://doi.org/10.5562/cca1817
MLA 8th Edition
Skelin, Ivan, et al. "Neurochemical and Behavioural Changes in Rat Models of Depression." Croatica Chemica Acta, vol. 84, br. 2, 2011, str. 287-299. https://doi.org/10.5562/cca1817. Citirano 04.03.2021.
Chicago 17th Edition
Skelin, Ivan, Tomislav Kovačević i Mirko Diksic. "Neurochemical and Behavioural Changes in Rat Models of Depression." Croatica Chemica Acta 84, br. 2 (2011): 287-299. https://doi.org/10.5562/cca1817
Harvard
Skelin, I., Kovačević, T., i Diksic, M. (2011). 'Neurochemical and Behavioural Changes in Rat Models of Depression', Croatica Chemica Acta, 84(2), str. 287-299. https://doi.org/10.5562/cca1817
Vancouver
Skelin I, Kovačević T, Diksic M. Neurochemical and Behavioural Changes in Rat Models of Depression. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 04.03.2021.];84(2):287-299. https://doi.org/10.5562/cca1817
IEEE
I. Skelin, T. Kovačević i M. Diksic, "Neurochemical and Behavioural Changes in Rat Models of Depression", Croatica Chemica Acta, vol.84, br. 2, str. 287-299, 2011. [Online]. https://doi.org/10.5562/cca1817

Sažetak
Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence.
The study of human depression is hindered by the relatively significant heterogeneity of this disorder.
As a result of these heterogeneities, studies using a sound and representative animal model of depression
are extremely valuable and, in general, provide important information regarding the neurochemical/
biological changes occurring during depression and the subsequent treatment of its symptoms. In this
review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and
Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics
of a good animal model; face, predictive and constructive validities. We also emphasize the
brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi:
10.5562/cca1817)

Ključne riječi
depression; olfactory bulbectomized rat model of depression; Flinders sensitive line rat; Flinders Resistant line rat; animal model of depression

Hrčak ID: 71992

URI
https://hrcak.srce.hr/71992

Posjeta: 1.834 *