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Pregledni rad
https://doi.org/10.5562/cca1817
Neurochemical and Behavioural Changes in Rat Models of Depression
Ivan Skelin
; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada
Tomislav Kovačević
; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia
Mirko Diksic
orcid.org/0000-0001-8070-6051
; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia
| Puni tekst: engleski, pdf (1 MB) | str. 287-299 | citiraj | |
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APA 6th Edition Skelin, I., Kovačević, T. i Diksic, M. (2011). Neurochemical and Behavioural Changes in Rat Models of Depression. Croatica Chemica Acta, 84 (2), 287-299. https://doi.org/10.5562/cca1817 MLA 8th Edition Skelin, Ivan, et al. "Neurochemical and Behavioural Changes in Rat Models of Depression." Croatica Chemica Acta, vol. 84, br. 2, 2011, str. 287-299. https://doi.org/10.5562/cca1817. Citirano 04.03.2021. Chicago 17th Edition Skelin, Ivan, Tomislav Kovačević i Mirko Diksic. "Neurochemical and Behavioural Changes in Rat Models of Depression." Croatica Chemica Acta 84, br. 2 (2011): 287-299. https://doi.org/10.5562/cca1817 Harvard Skelin, I., Kovačević, T., i Diksic, M. (2011). 'Neurochemical and Behavioural Changes in Rat Models of Depression', Croatica Chemica Acta, 84(2), str. 287-299. https://doi.org/10.5562/cca1817 Vancouver Skelin I, Kovačević T, Diksic M. Neurochemical and Behavioural Changes in Rat Models of Depression. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 04.03.2021.];84(2):287-299. https://doi.org/10.5562/cca1817 IEEE I. Skelin, T. Kovačević i M. Diksic, "Neurochemical and Behavioural Changes in Rat Models of Depression", Croatica Chemica Acta, vol.84, br. 2, str. 287-299, 2011. [Online]. https://doi.org/10.5562/cca1817 |
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Sažetak
Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence.
The study of human depression is hindered by the relatively significant heterogeneity of this disorder.
As a result of these heterogeneities, studies using a sound and representative animal model of depression
are extremely valuable and, in general, provide important information regarding the neurochemical/
biological changes occurring during depression and the subsequent treatment of its symptoms. In this
review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and
Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics
of a good animal model; face, predictive and constructive validities. We also emphasize the
brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi:
10.5562/cca1817)
Ključne riječi
depression; olfactory bulbectomized rat model of depression; Flinders sensitive line rat; Flinders Resistant line rat; animal model of depression
Hrčak ID: 71992
URI
https://hrcak.srce.hr/71992
Moj profil
Srce