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The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy

Renata Gržetić-Lenac
Maja Merlak
Tihomir Balog
Vedran Markušić
Iva Dekaris

Puni tekst: engleski, pdf (51 KB) str. 171-173 preuzimanja: 348* citiraj
APA 6th Edition
Gržetić-Lenac, R., Merlak, M., Balog, T., Markušić, V. i Dekaris, I. (2011). The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy. Collegium antropologicum, 35 - supplement 2 (2), 171-173. Preuzeto s https://hrcak.srce.hr/72259
MLA 8th Edition
Gržetić-Lenac, Renata, et al. "The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy." Collegium antropologicum, vol. 35 - supplement 2, br. 2, 2011, str. 171-173. https://hrcak.srce.hr/72259. Citirano 23.11.2019.
Chicago 17th Edition
Gržetić-Lenac, Renata, Maja Merlak, Tihomir Balog, Vedran Markušić i Iva Dekaris. "The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy." Collegium antropologicum 35 - supplement 2, br. 2 (2011): 171-173. https://hrcak.srce.hr/72259
Harvard
Gržetić-Lenac, R., et al. (2011). 'The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy', Collegium antropologicum, 35 - supplement 2(2), str. 171-173. Preuzeto s: https://hrcak.srce.hr/72259 (Datum pristupa: 23.11.2019.)
Vancouver
Gržetić-Lenac R, Merlak M, Balog T, Markušić V, Dekaris I. The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy. Collegium antropologicum [Internet]. 2011 [pristupljeno 23.11.2019.];35 - supplement 2(2):171-173. Dostupno na: https://hrcak.srce.hr/72259
IEEE
R. Gržetić-Lenac, M. Merlak, T. Balog, V. Markušić i I. Dekaris, "The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy", Collegium antropologicum, vol.35 - supplement 2, br. 2, str. 171-173, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/72259. [Citirano: 23.11.2019.]

Sažetak
Bullous keratopathy (BK) is a chronic corneal edema with or without subepithelial bullae as a result of a loss of the
endothelial cells. 15 patients with BK after cataract surgery with intraocular lens implantation, due to Fuchs dystrophy
(n=3) or corneal endothelial trauma (n=12) were included in the study. All patients were treated by amniotic membrane
transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91±3.09 pg/mL of IL-1 alpha,
4446±16.8 pg/mL of TNF and 81.43±37.81 pg/mL of VEGF-I. Levels of all 3 investigated cytokines were significantly
higher as compared to controls (p<0.005). Amniotic membranes that were used to treat investigated patients contained
638.98±613.98 pg/mL of IL-1ra, 0.026±0.009 pg/mL of sTNF and 81.39±21.01 pg/mL of VEGF-R. Beneficial clinical effect
of the AMT in treating BK could be explained by its natural production of pro-inflammatory cytokine antagonists
such as IL-ra, sTNF antagonist and VEGF-R.

Ključne riječi
amniotic membrane; bullous keratopathy; cytokines

Hrčak ID: 72259

URI
https://hrcak.srce.hr/72259

Posjeta: 522 *