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Original scientific paper

Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria

Marija Bilić
Radenka Munjas-Samarin
Danica Ljubanović
Ivica Horvatić
Krešimir Galešić

Fulltext: english, pdf (106 KB) pages 1061-1066 downloads: 310* cite
APA 6th Edition
Bilić, M., Munjas-Samarin, R., Ljubanović, D., Horvatić, I. & Galešić, K. (2011). Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria. Collegium antropologicum, 35 (4), 1061-1066. Retrieved from https://hrcak.srce.hr/75608
MLA 8th Edition
Bilić, Marija, et al. "Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria." Collegium antropologicum, vol. 35, no. 4, 2011, pp. 1061-1066. https://hrcak.srce.hr/75608. Accessed 19 Aug. 2019.
Chicago 17th Edition
Bilić, Marija, Radenka Munjas-Samarin, Danica Ljubanović, Ivica Horvatić and Krešimir Galešić. "Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria." Collegium antropologicum 35, no. 4 (2011): 1061-1066. https://hrcak.srce.hr/75608
Harvard
Bilić, M., et al. (2011). 'Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria', Collegium antropologicum, 35(4), pp. 1061-1066. Available at: https://hrcak.srce.hr/75608 (Accessed 19 August 2019)
Vancouver
Bilić M, Munjas-Samarin R, Ljubanović D, Horvatić I, Galešić K. Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria. Collegium antropologicum [Internet]. 2011 [cited 2019 August 19];35(4):1061-1066. Available from: https://hrcak.srce.hr/75608
IEEE
M. Bilić, R. Munjas-Samarin, D. Ljubanović, I. Horvatić and K. Galešić, "Effects of Ramipril and Valsartan on Proteinuria and Renal Function in Patients with Nondiabetic Proteinuria", Collegium antropologicum, vol.35, no. 4, pp. 1061-1066, 2011. [Online]. Available: https://hrcak.srce.hr/75608. [Accessed: 19 August 2019]

Abstracts
The renin-angiotensin system is involved in the progression of chronic renal disease of both diabetic and nondiabetic
origin. The angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers have been demonstrated to reduce
urinary protein excretion and attenuate the development of renal injury. This prospective, randomized, 12-month
study assessed the effects of ramipril (N=23) vs. valsartan (N=22) vs. combination of ramipril and valsartan (N=26) on
proteinuria, renal function and metabolic profile in 71 patients with nondiabetic proteinuria with normal or slightly impaired
renal function. Monotherapy with ramipril or valsartan and combination of these two drugs significantly reduced
proteinuria, serum creatinine, cholesterol and triglycerides as well as systolic and diastolic arterial blood pressure.
There was no significant difference among three study groups according to reduction of arterial blood pressure,
serum cholesterol and triglycerides. At one year, a significant reduction in serum creatinine was recorded in all three
study groups, whereas at 3 and 6 months a statistically significant reduction in serum creatinine was only observed in
patients on combination therapy. In addition, at 3 months the reduction of proteinuria was significantly greater in patients
on combination therapy than in those on either monotherapy. These results indicated the combination therapy with
angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers to be more efficacious than either monotherapy
in reducing proteinuria and serum creatinine level in the first 3 (proteinuria and serum creatinine) or 6 (serum
creatinine) months of treatment.

Keywords
angiotensin-converting enzyme inhibitors; angiotensin II receptors blockers; proteinuria; renoprotection

Hrčak ID: 75608

URI
https://hrcak.srce.hr/75608

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