hrcak mascot   Srce   HID

Izvorni znanstveni članak

Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma

Gordana Jakovljević
Srđana Čulić
Jasminka Stepan
Iva Košuta
Sven Seiwerth

Puni tekst: engleski, pdf (244 KB) str. 1071-1079 preuzimanja: 192* citiraj
APA 6th Edition
Jakovljević, G., Čulić, S., Stepan, J., Košuta, I. i Seiwerth, S. (2011). Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma. Collegium antropologicum, 35 (4), 1071-1079. Preuzeto s https://hrcak.srce.hr/75610
MLA 8th Edition
Jakovljević, Gordana, et al. "Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma." Collegium antropologicum, vol. 35, br. 4, 2011, str. 1071-1079. https://hrcak.srce.hr/75610. Citirano 18.11.2019.
Chicago 17th Edition
Jakovljević, Gordana, Srđana Čulić, Jasminka Stepan, Iva Košuta i Sven Seiwerth. "Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma." Collegium antropologicum 35, br. 4 (2011): 1071-1079. https://hrcak.srce.hr/75610
Harvard
Jakovljević, G., et al. (2011). 'Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma', Collegium antropologicum, 35(4), str. 1071-1079. Preuzeto s: https://hrcak.srce.hr/75610 (Datum pristupa: 18.11.2019.)
Vancouver
Jakovljević G, Čulić S, Stepan J, Košuta I, Seiwerth S. Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma. Collegium antropologicum [Internet]. 2011 [pristupljeno 18.11.2019.];35(4):1071-1079. Dostupno na: https://hrcak.srce.hr/75610
IEEE
G. Jakovljević, S. Čulić, J. Stepan, I. Košuta i S. Seiwerth, "Relationship Between Tumor Vascularity and Vascular Endothelial Growth Factor as Prognostic Factors for Patients with Neuroblastoma", Collegium antropologicum, vol.35, br. 4, str. 1071-1079, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/75610. [Citirano: 18.11.2019.]

Sažetak
Although the role of angiogenesis in tumor progression and response to treatment is generally well-characterized, for
neuroblastomas clinical data regarding the contribution of angiogenesis and its predictive capacity remain unclear. The
aim of this study was to evaluate whether tumor vascularity in the combination with expression of vascular endothelial
growth factor (VEGF) represent prognostic factors for patients with neuroblastoma. Immunohistochemistry using anti-
-CD34 and anti-VEGF antibodies was used to analyze paraffin-embedded primary tumor tissues from 56 patients diagnosed
with neuroblastoma. Tumor vascularity was estimated by calculating the tumor vascular volume fraction (TVVF),
and VEGF expression was determined using semi-quantitative scoring. Statistical analyses including multivariate analysis
were performed and compared with these two factors. Tumor vascularity had impact on survival of high VEGF expression
neuroblastoma patients. Combination of high VEGF expression and TVVF value 5% was independent predictor
of overall survival (p-value =0.0041, odds ratio (OR) (95%CI)=8.67 (1.99–37.69) by the Cox proportional hazards
model). This study revealed for the first time a group of extremely high-risk neuroblastoma with both high VEGF expression
and poor vascularity. For these patients reduced rates of survival were observed (37% vs. 92.5%) (p<0.0001). These
patients did not experience a significant improvement following hematopoietic stem cell transplantation, and could be
candidates for receiving novel therapies. These results indicate the importance of the mutual relationship between tumor
vascularity and VEGF, because it gives better insight into the prognosis of patients with neuroblastoma.

Ključne riječi
neuroblastoma; tumor angiogenesis; vascular endothelial growth factor; hypoxia; survival

Hrčak ID: 75610

URI
https://hrcak.srce.hr/75610

Posjeta: 316 *