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Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder

Marina Čeprnja
Lovorka Đerek
Adriana Unić
Martina Blažev
Marina Fistonić
Dragica Kozarić-Kovačić
Miljenko Franić
Željko Romić

Puni tekst: engleski, pdf (97 KB) str. 1155-1160 preuzimanja: 406* citiraj
APA 6th Edition
Čeprnja, M., Đerek, L., Unić, A., Blažev, M., Fistonić, M., Kozarić-Kovačić, D., ... Romić, Ž. (2011). Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder. Collegium antropologicum, 35 (4), 1155-1160. Preuzeto s https://hrcak.srce.hr/75626
MLA 8th Edition
Čeprnja, Marina, et al. "Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder." Collegium antropologicum, vol. 35, br. 4, 2011, str. 1155-1160. https://hrcak.srce.hr/75626. Citirano 12.11.2019.
Chicago 17th Edition
Čeprnja, Marina, Lovorka Đerek, Adriana Unić, Martina Blažev, Marina Fistonić, Dragica Kozarić-Kovačić, Miljenko Franić i Željko Romić. "Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder." Collegium antropologicum 35, br. 4 (2011): 1155-1160. https://hrcak.srce.hr/75626
Harvard
Čeprnja, M., et al. (2011). 'Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder', Collegium antropologicum, 35(4), str. 1155-1160. Preuzeto s: https://hrcak.srce.hr/75626 (Datum pristupa: 12.11.2019.)
Vancouver
Čeprnja M, Đerek L, Unić A, Blažev M, Fistonić M, Kozarić-Kovačić D i sur. Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder. Collegium antropologicum [Internet]. 2011 [pristupljeno 12.11.2019.];35(4):1155-1160. Dostupno na: https://hrcak.srce.hr/75626
IEEE
M. Čeprnja, et al., "Oxidative Stress Markers in Patients with Post-Traumatic Stress Disorder", Collegium antropologicum, vol.35, br. 4, str. 1155-1160, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/75626. [Citirano: 12.11.2019.]

Sažetak
Recent study data support the role of oxidative stress in diverse psychiatric disorders. Oxidative stress results from an
oxidant/antioxidant imbalance, an excess of oxidants and/or a depletion of antioxidants. There are numerous studies
that indicate that free radicals (FRs) damage neurons, and then play an important role in the pathophysiology of schizophrenia
and depression. Active oxygen can cause considerable damage and disrupt the important physiological functions
of proteins, lipids, enzymes and DNA. The aim of our study was to investigate the possible differences in the concentration
of tromboxane B2, 8-OHdG and protein carbonyls, as significant markers of oxidative damage, and urate, albumin
and total protein concentrations as antioxidative molecules in PTSD patients in comparison to the healthy control group.
The study included 74 male participants who were active soldiers in the Croatian armed forces from 1991 to 1995. 46
subjects with chronic and current PTSD were recruited from the Department of Psychiatry of Dubrava University Hospital
during 2010, 28 healthy subjects were recruited in the same period during the regular medical examination at the
Dubrava University Hospital. Study results have shown that there is no statistically significant difference in urinary
concentrations of 8-OHdG, serum thromboxane B2, and serum urates between two studied groups. Statistically significant
difference of the protein carbonyl concentrations was examined. Concentrations were significantly lower in the
PTSD group than in the control group. The clinical significance of these results was examined using ROC analysis. The
obtained ROC curves did not separate the groups in a satisfactory manner.

Ključne riječi
free radicals; 8-hydroxy-2’-deoxyguanosine; oxidative stress; post-traumatic stress disorder; protein carbonyls; thromboxane B2

Hrčak ID: 75626

URI
https://hrcak.srce.hr/75626

Posjeta: 546 *