hrcak mascot   Srce   HID

Acta Pharmaceutica, Vol.62 No.1 Ožujak 2012.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-012-0007-0

Sinteza i potencijalno biološko djelovanje novih 3-((N-supstituiranih indol-3-il)metilenamino)-6-amino-4-aril-pirano(2,3-c)pirazol-5-karbonitrila i 3,6-diamino-4-(N-supstituiranih indol-3-il)pirano(2,3-c)pirazol-5-karbonitrila

ADEL HAMED MANDOUR ; Chemistry Department of Natural Compounds, National Research Centre, Cairo, Egypt
ESLAM REDA EL-SAWY ; Chemistry Department of Natural Compounds, National Research Centre, Cairo, Egypt
MANAL SHAABAN EBAID ; Chemistry Department of Natural Compounds, National Research Centre, Cairo, Egypt
SEHAM M. HASSAN ; Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Cairo, Egypt

Puni tekst: engleski, pdf (107 KB) str. 15-30 preuzimanja: 625* citiraj
APA 6th Edition
MANDOUR, A.H., EL-SAWY, E.R., EBAID, M.S. i HASSAN, S.M. (2012). Synthesis and potential biological activity of some novel 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles. Acta Pharmaceutica, 62 (1), 15-30. https://doi.org/10.2478/v10007-012-0007-0
MLA 8th Edition
MANDOUR, ADEL HAMED, et al. "Synthesis and potential biological activity of some novel 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles." Acta Pharmaceutica, vol. 62, br. 1, 2012, str. 15-30. https://doi.org/10.2478/v10007-012-0007-0. Citirano 17.07.2018.
Chicago 17th Edition
MANDOUR, ADEL HAMED, ESLAM REDA EL-SAWY, MANAL SHAABAN EBAID i SEHAM M. HASSAN. "Synthesis and potential biological activity of some novel 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles." Acta Pharmaceutica 62, br. 1 (2012): 15-30. https://doi.org/10.2478/v10007-012-0007-0
Harvard
MANDOUR, A.H., et al. (2012). 'Synthesis and potential biological activity of some novel 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles', Acta Pharmaceutica, 62(1), str. 15-30. doi: https://doi.org/10.2478/v10007-012-0007-0
Vancouver
MANDOUR AH, EL-SAWY ER, EBAID MS, HASSAN SM. Synthesis and potential biological activity of some novel 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles. Acta Pharm. [Internet]. 31.03.2012. [pristupljeno 17.07.2018.];62(1):15-30. doi: https://doi.org/10.2478/v10007-012-0007-0
IEEE
A.H. MANDOUR, E.R. EL-SAWY, M.S. EBAID i S.M. HASSAN, "Synthesis and potential biological activity of some novel 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles", Acta Pharmaceutica, vol.62, br. 1, str. 15-30, July 2018. [Online]. doi: https://doi.org/10.2478/v10007-012-0007-0

Sažetak
U radu se opisuje sinteza novih 3-(N-supstituiranih indol-3-il)metilenamino-6-amino-4-aril-pirano(2,3-c) pirazol-5-karbonitrila (3a-g i 4a-g) kiselo-kataliziranom kondenzacijom N-supstituiranih indol-3-karboksaldehida (1a-g) s 3-amino-5-pirazolonom iza koje slijedi reakcija s ariliden malononitrilom. Serija novih 3,6-diamino-4-(N-supstituiranih indol-3-il)pirano(2,3-c)pirazol-5-karbonitrila (7a-g) sintetizirana je reakcijom malononitrila s produktima 6a-g, koji su pripravljeni bazno-kataliziranom kondenzacijom 1a-g s 3-amino-5-pirazolonom. Neki spojevi iz serije 7a-g dobiveni su reakcijom N-supstituiranih 3-indolidin malononitrila (5a-g) s 3-amino-5-pirazolonom. Novosintetizirani spojevi imaju značajno protuupalno, analgetsko i antikonvulzivno djelovanje. Antikonvulzivno djelovanje pojedinih testiranih spojeva bilo je jače izraženo nego protuupalno i analgetsko djelovanje. Većina ispitivanih spojeva pokazuje antimikrobno djelovanje na Escherichia coli i Pseudomonas aeruginosa.

Ključne riječi
indol; pirano(2,3-c)pirazol; protuupalno; analgetsko; antikonvulzivno; antimikrobno djelovanje

Hrčak ID: 76601

URI
https://hrcak.srce.hr/76601

[engleski]

Posjeta: 865 *