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A Critique of Race-Based and Genomic Medicine

Robert J. Meier

Puni tekst: engleski, pdf (73 KB) str. 5-10 preuzimanja: 382* citiraj
APA 6th Edition
Meier, R.J. (2012). A Critique of Race-Based and Genomic Medicine. Collegium antropologicum, 36 (1), 5-10. Preuzeto s https://hrcak.srce.hr/78776
MLA 8th Edition
Meier, Robert J.. "A Critique of Race-Based and Genomic Medicine." Collegium antropologicum, vol. 36, br. 1, 2012, str. 5-10. https://hrcak.srce.hr/78776. Citirano 14.11.2019.
Chicago 17th Edition
Meier, Robert J.. "A Critique of Race-Based and Genomic Medicine." Collegium antropologicum 36, br. 1 (2012): 5-10. https://hrcak.srce.hr/78776
Harvard
Meier, R.J. (2012). 'A Critique of Race-Based and Genomic Medicine', Collegium antropologicum, 36(1), str. 5-10. Preuzeto s: https://hrcak.srce.hr/78776 (Datum pristupa: 14.11.2019.)
Vancouver
Meier RJ. A Critique of Race-Based and Genomic Medicine. Collegium antropologicum [Internet]. 2012 [pristupljeno 14.11.2019.];36(1):5-10. Dostupno na: https://hrcak.srce.hr/78776
IEEE
R.J. Meier, "A Critique of Race-Based and Genomic Medicine", Collegium antropologicum, vol.36, br. 1, str. 5-10, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/78776. [Citirano: 14.11.2019.]

Sažetak
Now that a composite human genome has been sequenced (HGP), research has accelerated to discover precise genetic bases of several chronic health issues, particularly in the realms of cancer and cardiovascular disease. It is anticipated that in the future it will be possible and cost effective to regularly sequence individual genomes, and thereby produce a DNA profile that potentially can be used to assess the health risks for each person with respect to certain genetically predisposed conditions. Coupled with that enormous diagnostic power, it will then depend upon equally rapid research efforts to develop personalized courses of treatment, including that of pharmaceutical therapy. Initial treatment attempts have been made to match drug efficacy and safety to individuals of assigned or self-identified groups according to their genetic ancestry or presumed race. A prime example is that of BiDil, which was the first drug approved by the US FDA for the explicit treatment of heart patients of African American ancestry. This race-based approach to medicine has been met with justifiable criticism, notably on ethical grounds that have long plagued historical applications and misuses of human race classification, and also on questionable science. This paper will assess race-based medical research and practice in light of a more thorough understanding of human genetic variability. Additional concerns will be expressed with regard to the rapidly developing area of pharmacogenomics, promoted to be the future of personalized medicine. Genomic epidemiology will be discussed with several examples of on-going research that hopefully will provide a solid scientific grounding for personalized medicine to build upon.

Ključne riječi
race-based medicine; BiDil; pharmacogenomics; genomic epidemiology; personalized medicine

Hrčak ID: 78776

URI
https://hrcak.srce.hr/78776

Posjeta: 564 *