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Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors

Biserka Pigac
Branko Dmitrović
Svjetlana Marić
Silvija Mašić

Puni tekst: engleski, pdf (75 KB) str. 227-233 preuzimanja: 261* citiraj
APA 6th Edition
Pigac, B., Dmitrović, B., Marić, S. i Mašić, S. (2012). Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors. Collegium antropologicum, 36 (1), 227-233. Preuzeto s https://hrcak.srce.hr/78817
MLA 8th Edition
Pigac, Biserka, et al. "Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors." Collegium antropologicum, vol. 36, br. 1, 2012, str. 227-233. https://hrcak.srce.hr/78817. Citirano 13.11.2019.
Chicago 17th Edition
Pigac, Biserka, Branko Dmitrović, Svjetlana Marić i Silvija Mašić. "Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors." Collegium antropologicum 36, br. 1 (2012): 227-233. https://hrcak.srce.hr/78817
Harvard
Pigac, B., et al. (2012). 'Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors', Collegium antropologicum, 36(1), str. 227-233. Preuzeto s: https://hrcak.srce.hr/78817 (Datum pristupa: 13.11.2019.)
Vancouver
Pigac B, Dmitrović B, Marić S, Mašić S. Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors. Collegium antropologicum [Internet]. 2012 [pristupljeno 13.11.2019.];36(1):227-233. Dostupno na: https://hrcak.srce.hr/78817
IEEE
B. Pigac, B. Dmitrović, S. Marić i S. Mašić, "Cathepsin D and Its Prognostic Value in Neuroepithelial Brain Tumors", Collegium antropologicum, vol.36, br. 1, str. 227-233, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/78817. [Citirano: 13.11.2019.]

Sažetak
Expression of Cathepsin D (Cath D) in some primary neuroepithelial brain tumors and its prognostic value were studied. The research included 65 samples of human primary neuroepithelial brain tumors. There were 50 glial tumors (10 diffuse astrocytomas (DA), 15 anaplastic astrocytomas (AA), 25 glioblastomas (GB), 15 embryonic tumors (15 medulloblastomas (MB) as well as 5 samples of normal brain tissue. Immunohistochemical method was applied to monitor diffuse positive reaction in the cytoplasm of brain tumor cells, endothelial cells and tumor stromal cells and showed diffuse positive reaction for Cath D in the cytoplasm of brain tumor cells, endothelial cells and stromal cells in all analyzed samples of DA, AA, GB and MB as well as in microglial cells, neurons and in endothelial cells in all analyzed samples of normal brain tissue. Qualitative analysis of Cath D expression in the cytoplasm of brain tumor cells and endothelial cells as well as the percentage of brain tumor cells, endothelial cells and stromal cells immunopositive for Cath D showed that there was difference between analyzed brain tumor groups, but according to statistical tests the difference was not statistically significant. Survival correlated with the percentage of stromal cells immunopositive for Cath D. Survival prognosis was influenced by the percentage of stromal cells immunopositive for Cath D and tumor grade. The obtained results singled out the percentage of stromal cells immunopositive for Cath D as an independent parameter. The results of this research on the prognostic value of Cath D in some primary brain tumors of neuroepithelial origin indicate that there is real possibility to use Cath D as an independent prognostic factor in human glioma progression and thus open up possibilities for further scientific research.

Ključne riječi
cathepsin D; prognostic value; glioma; medulloblastoma

Hrčak ID: 78817

URI
https://hrcak.srce.hr/78817

Posjeta: 445 *