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https://doi.org/10.5562/cca1802

4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors

Yousery El-Sayed Sherif ; Department of Chemistry, Faculty of Science and Arts, Olla, Taibah University, Kingdom of Saudi Arabia
Ahmed Abdel-Hamid El-Asmy ; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
Mahmoud Lotfy ; Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Minufiya University, Sadat City, Minufiya, Egypt

Puni tekst: engleski, pdf (1 MB) str. 19-26 preuzimanja: 1.262* citiraj
APA 6th Edition
Sherif, Y.E., El-Asmy, A.A. i Lotfy, M. (2012). 4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors. Croatica Chemica Acta, 85 (1), 19-26. https://doi.org/10.5562/cca1802
MLA 8th Edition
Sherif, Yousery El-Sayed, et al. "4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors." Croatica Chemica Acta, vol. 85, br. 1, 2012, str. 19-26. https://doi.org/10.5562/cca1802. Citirano 25.02.2021.
Chicago 17th Edition
Sherif, Yousery El-Sayed, Ahmed Abdel-Hamid El-Asmy i Mahmoud Lotfy. "4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors." Croatica Chemica Acta 85, br. 1 (2012): 19-26. https://doi.org/10.5562/cca1802
Harvard
Sherif, Y.E., El-Asmy, A.A., i Lotfy, M. (2012). '4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors', Croatica Chemica Acta, 85(1), str. 19-26. https://doi.org/10.5562/cca1802
Vancouver
Sherif YE, El-Asmy AA, Lotfy M. 4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors. Croatica Chemica Acta [Internet]. 2012 [pristupljeno 25.02.2021.];85(1):19-26. https://doi.org/10.5562/cca1802
IEEE
Y.E. Sherif, A.A. El-Asmy i M. Lotfy, "4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors", Croatica Chemica Acta, vol.85, br. 1, str. 19-26, 2012. [Online]. https://doi.org/10.5562/cca1802

Sažetak
4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) as nonsteroidal antiinflammatory drug (NSAIDs) of oxicam family has been synthesized bearing high se-lectivity for cyclooxygenase-2 (COX-2) inhibition and high ability to chelate with Cu(II) ions. The EX15-Cu(II) complex, and [Cu(EX15)(OAc)(H2O)2], were synthesized and characterized by using elemental analysis, spectral (UV-Vis, IR), conductance, thermal and magnetic studies. Two equations were predicted using quantitative structure activity relationship (QSAR) and regression analysis for the COX-2 and COX-1 selectivity (microsomal assay) with a regression correlation (R) close to unity. Two techniques were used to investigate the validity of these equations; macrophage cell line (in vitro) selectivity and collagen-adjuvant arthritis model in rats (in vivo) which showed a significant antioxidant, analgesic and antirheumatic effect for 4-hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide and its Cu(II) complex, [Cu(EX15)(OAc)(H2O)2]. (doi: 10.5562/cca1802)

Ključne riječi
Oxicam; metal complexes; analgesic; rheumatoid; anti-inflammatory

Hrčak ID: 80399

URI
https://hrcak.srce.hr/80399

Posjeta: 1.657 *