Pregledni rad
Clinical Aspects of Infections Caused by Methicillin-Resistant Staphylococcus aureus
Bruno Baršić
; University of Zagreb, School of Medicine, Hospital for Infectious Diseases “Dr Fran Mihaljević”, Zagreb, Croatia
Sažetak
Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of nosocomial infections. Clinical presentation of infections is determined by the way of the acquisition of the pathogen then by virulence factors itself. In the intensive care units MRSA causes blood stream infections (BSI) associated with the use of venous lines as well as ventilator-associated pneumonia (VAP). MRSA is prone to form biofilm on implanted foreign materials like orthopaedic and other prostheses, catheters, artificial heart valves and cause persistent infections of surrounding tissues which are difficult to treat. It is difficult to eradicate infection without extraction of these materials. MRSA is weaker inductor of general inflammatory reaction then MSSA. Increase in patient’s mortality and morbidity is associated more with a delay of appropriate antibiotic treatment then severity of infection. New antibiotics like linezolid, daptomycin, tygecycline, ceftarolin, ceftobiprol are available nowadays for the treatment of these infections. Although glycopeptides are still the first line treatment of MRSA infections, increase of minimal inhibitory concentrations (MIC creep) is associated with poorer outcome.
Ključne riječi
Hrčak ID:
84031
URI
Datum izdavanja:
21.5.2012.
Posjeta: 2.390 *