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https://doi.org/10.5562/cca1816

Early Endosomal Retention of Murine Cytomegalovirus m06 Protein

Natalia Kučić ; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Maja Ilić Tomaš ; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Hana Mahmutefendić ; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Gordana Blagojević ; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia
Pero Lučin ; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Braće Branchetta 20, HR-51000 Rijeka, Croatia

Puni tekst: engleski, pdf (5 MB) str. 213-221 preuzimanja: 675* citiraj
APA 6th Edition
Kučić, N., Ilić Tomaš, M., Mahmutefendić, H., Blagojević, G. i Lučin, P. (2012). Early Endosomal Retention of Murine Cytomegalovirus m06 Protein. Croatica Chemica Acta, 85 (2), 213-221. https://doi.org/10.5562/cca1816
MLA 8th Edition
Kučić, Natalia, et al. "Early Endosomal Retention of Murine Cytomegalovirus m06 Protein." Croatica Chemica Acta, vol. 85, br. 2, 2012, str. 213-221. https://doi.org/10.5562/cca1816. Citirano 28.11.2020.
Chicago 17th Edition
Kučić, Natalia, Maja Ilić Tomaš, Hana Mahmutefendić, Gordana Blagojević i Pero Lučin. "Early Endosomal Retention of Murine Cytomegalovirus m06 Protein." Croatica Chemica Acta 85, br. 2 (2012): 213-221. https://doi.org/10.5562/cca1816
Harvard
Kučić, N., et al. (2012). 'Early Endosomal Retention of Murine Cytomegalovirus m06 Protein', Croatica Chemica Acta, 85(2), str. 213-221. https://doi.org/10.5562/cca1816
Vancouver
Kučić N, Ilić Tomaš M, Mahmutefendić H, Blagojević G, Lučin P. Early Endosomal Retention of Murine Cytomegalovirus m06 Protein. Croatica Chemica Acta [Internet]. 2012 [pristupljeno 28.11.2020.];85(2):213-221. https://doi.org/10.5562/cca1816
IEEE
N. Kučić, M. Ilić Tomaš, H. Mahmutefendić, G. Blagojević i P. Lučin, "Early Endosomal Retention of Murine Cytomegalovirus m06 Protein", Croatica Chemica Acta, vol.85, br. 2, str. 213-221, 2012. [Online]. https://doi.org/10.5562/cca1816

Sažetak
Murine cytomegalovirus (MCMV) encodes several genes which products interact with MHC
class I molecules (MHC-I) in the secretory pathway to evade antigen presentation. The product of
MCMV-m06 gene associates with nascent MHC-I proteins and redirects them into lysosomes for degradation.
This report will demonstrate that MCMV-m06 protein is retained in perinuclear early endosomes together
with internalized MHC-I molecules. Since we were not able to capture the MCMV-m06 protein on
the cell surface, our data suggests that the MCMV-m06 protein is transported from the Golgi into early
endosomal intermediates prior to their maturation into multivesicular endosomes and lysosomes. In NIH
3T3 cells with the transfected m06 gene, the endosomal localization of the m06 protein was not observed,
suggesting that another MCMV function remodels the route of m06 trafficking from the Golgi towards
late endosomes. (doi: 10.5562/cca1816)

Ključne riječi
murine cytomegalovirus; m06/gp48; major histocompatibility class I molecules; early endosomal retention

Hrčak ID: 84540

URI
https://hrcak.srce.hr/84540

Posjeta: 935 *