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Original scientific paper

Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia

Ivana Mareković
Vanda Plečko
Zagorka Boras
Ladislav Pavlović
Ana Budimir
Zrinka Bošnjak
Hrvoje Puretić
Lidija Žele-Starčević
Smilja Kalenić

Fulltext: english, pdf (91 KB) pages 401-408 downloads: 211* cite
APA 6th Edition
Mareković, I., Plečko, V., Boras, Z., Pavlović, L., Budimir, A., Bošnjak, Z., ... Kalenić, S. (2012). Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia. Collegium antropologicum, 36 (2), 401-408. Retrieved from https://hrcak.srce.hr/84776
MLA 8th Edition
Mareković, Ivana, et al. "Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia." Collegium antropologicum, vol. 36, no. 2, 2012, pp. 401-408. https://hrcak.srce.hr/84776. Accessed 29 Mar. 2020.
Chicago 17th Edition
Mareković, Ivana, Vanda Plečko, Zagorka Boras, Ladislav Pavlović, Ana Budimir, Zrinka Bošnjak, Hrvoje Puretić, Lidija Žele-Starčević and Smilja Kalenić. "Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia." Collegium antropologicum 36, no. 2 (2012): 401-408. https://hrcak.srce.hr/84776
Harvard
Mareković, I., et al. (2012). 'Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia', Collegium antropologicum, 36(2), pp. 401-408. Available at: https://hrcak.srce.hr/84776 (Accessed 29 March 2020)
Vancouver
Mareković I, Plečko V, Boras Z, Pavlović L, Budimir A, Bošnjak Z, et al. Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia. Collegium antropologicum [Internet]. 2012 [cited 2020 March 29];36(2):401-408. Available from: https://hrcak.srce.hr/84776
IEEE
I. Mareković, et al., "Value of Rapid Aetiological Diagnosis in Optimization of Antimicrobial Treatment in Bacterial Community Acquired Pneumonia", Collegium antropologicum, vol.36, no. 2, pp. 401-408, 2012. [Online]. Available: https://hrcak.srce.hr/84776. [Accessed: 29 March 2020]

Abstracts
In 80 adult patients with community acquired pneumonia (CAP) conventional microbiological methods, polymerase
chain reaction (PCR) and serum C-reactive protein (CRP) levels were performed and the appropriateness of the empirical
antimicrobial treatment was evaluated according to bacterial pathogen detected. The aetiology was determined in 42
(52.5%) patients, with Streptococcus pneumoniae as the most common pathogen. PCR applied to bronchoalveolar lavage
(BAL) provided 2 and PCR on sputum samples 1 additional aetiological diagnosis of CAP. The mean CRP values in the
S. pneumoniae group were not significantly higher than in the group with other aetiological diagnoses (166.89 mg/L
vs.160.11 mg/L, p=0.457). In 23.8% (10/42) of patients with determined aetiology, the empirical antimicrobial treatment
was inappropriate. PCR tests need further investigation, particularly those for the atypical pathogens, as they are predominant
in inappropriately treated patients. Our results do not support the use of CRP as a rapid test to guide the
antimicrobial treatment in patients with CAP.

Keywords
community acquired pneumonia; PCR; antimicrobial treatment

Hrčak ID: 84776

URI
https://hrcak.srce.hr/84776

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