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Serologic Diagnosis of Syphilis: Comparison of Different Diagnostic Methods

Yunus Saral ; Department of Dermatology Rize Education and Research Hospital Rize Turkey
Aziz Ramazan Dilek ; Department of Microbiology Rize Education and Research Hospital Rize Turkey
Nursel Dilek ; Department of Dermatology Rize Education and Research Hospital Rize Turkey
İlkay Bahçeci ; Department of Microbiology Rize Education and Research Hospital Rize Turkey
Deniz Zehra Ulusan ; Department of Microbiology Rize Education and Research Hospital Rize Turkey

Full text is not available.

Abstracts
Diagnostic and therapeutic approaches in syphilis show wide
variation. The use of only one type of serologic test is insufficient for diagnosis.
However, current international recommendations cannot be applied
due to various reasons (cost, availability, etc.). The aim of the study was
to review serologic data of syphilis patients to determine diagnostic performance
of three different methods. In 117 patients suspected of having
syphilis, syphilis was diagnosed serologically and clinically. Three different
methods were used for detection of antibodies: Rapid Plasma Reagin (RPR),
Treponemal Chemiluminescence Microparticle Enzyme Immunoassay
(CMIA) and Treponema pallidum hemagglutination (TPHA). The sensitivity,
specificity, positive predictive value, negative predictive value and accuracy
were calculated for the former two methods against TPHA. The sensitivity of
RPR and CMIA against TPHA was 58% and 98%, respectively. The specificity
of RPR and CMIA against TPHA was 0% and 100%, respectively. Automated
enzyme immunoassay systems could contribute to reducing errors that depend
on the person, especially while monitoring titration changes.

Keywords
syphilis; Treponema pallidum; enzyme immunoassays; TPHA; RPR

Hrčak ID: 89095

URI
https://hrcak.srce.hr/89095

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