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https://doi.org/10.5562/cca1983

Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid

Kh. A. M. El-Bayouki ; Organometallic and Organometalloid Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt
W. M. Basyouni ; Organometallic and Organometalloid Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt
A. S. El-Sayed ; Chemistry Dept. Faculty of Science, Al-Azhar University, Cairo, Egypt
W. M. Tohamy ; Organometallic and Organometalloid Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt
A. A. El-Henawy ; Chemistry Dept. Faculty of Science, Al-Azhar University, Cairo, Egypt

Puni tekst: engleski, pdf (9 MB) str. 255-268 preuzimanja: 1.540* citiraj
APA 6th Edition
El-Bayouki, K.A.M., Basyouni, W.M., El-Sayed, A.S., Tohamy, W.M. i El-Henawy, A.A. (2012). Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid. Croatica Chemica Acta, 85 (3), 255-268. https://doi.org/10.5562/cca1983
MLA 8th Edition
El-Bayouki, Kh. A. M., et al. "Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid." Croatica Chemica Acta, vol. 85, br. 3, 2012, str. 255-268. https://doi.org/10.5562/cca1983. Citirano 06.03.2021.
Chicago 17th Edition
El-Bayouki, Kh. A. M., W. M. Basyouni, A. S. El-Sayed, W. M. Tohamy i A. A. El-Henawy. "Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid." Croatica Chemica Acta 85, br. 3 (2012): 255-268. https://doi.org/10.5562/cca1983
Harvard
El-Bayouki, K.A.M., et al. (2012). 'Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid', Croatica Chemica Acta, 85(3), str. 255-268. https://doi.org/10.5562/cca1983
Vancouver
El-Bayouki KAM, Basyouni WM, El-Sayed AS, Tohamy WM, El-Henawy AA. Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid. Croatica Chemica Acta [Internet]. 2012 [pristupljeno 06.03.2021.];85(3):255-268. https://doi.org/10.5562/cca1983
IEEE
K.A.M. El-Bayouki, W.M. Basyouni, A.S. El-Sayed, W.M. Tohamy i A.A. El-Henawy, "Highly Efficient One-pot Synthesis, Antimicrobial and Docking Studies of Newer β-amino Carbonyl Derivatives Catalyzed by Silica Sulfuric Acid", Croatica Chemica Acta, vol.85, br. 3, str. 255-268, 2012. [Online]. https://doi.org/10.5562/cca1983

Sažetak
Mannich reaction was applied between 4-fluorobezaldehyde, selected acetophenone and several anilines, catalyzed by silica sulfuric acid for the synthesis of β-amino carbonyl derivatives. Reaction time and yield of the products depended on the nature of acetophenone and aniline subsituents. Using aliphatic amines instead of aromatic amines under same reaction conditions, afforded aldol condensation products without yielding the expected β-amino ketones. Replacing the acetophenone derivatives with rhodanine yielded 5-(4-fluorobenzylidene)-thioxothiazolidin-4-one. Using 2-aminothiophenol instead of the aniline derivatives, 2-(4-fluorophenyl)benzothiazole was obtained without isolation of the expected (mercapto-phenylamino)-1-(4-substitutedphenyl)propan-1-ones. A proposed reaction mechanism was suggested. Docking studies were designed to gain clear picture of the high active compound(s). A model of high active molecules was mapped for the antimicrobial screening and compared with least active compound(s). (doi: 10.5562/cca1983)

Ključne riječi
multi-component reaction; Mannich reactions; β-aminoketones; silica sulfuric acid; docking studies

Hrčak ID: 91856

URI
https://hrcak.srce.hr/91856

Posjeta: 1.975 *