hrcak mascot   Srce   HID

Pregledni rad

PATHOPHYSIOLOGY OF DELIRIUM

TAJANA ZAH BOGOVIĆ ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia
DINKO TONKOVIĆ ; University of Zagreb, Department of Anesthesiology, Resuscitation and Intensive Care, Sveti Duh University Hospital, Zagreb, Croatia
ANTE SEKULIĆ ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia
DANIELA BANDIĆ-PAVLOVIĆ ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia
ROBERT BARONICA ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia
MARKO BOGOVIĆ ; University of Zagreb School of Medicine,University Department of Surgery, Zagreb, Croatia
SANJA SAKAN ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia
INA FILIPOVIĆ GRČIĆ ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia
BORIS TOMAŠEVIĆ TOMAŠEVIĆ ; University of Zagreb School of Medicine, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb University Hospital Center, Zagreb, Croatia

Puni tekst: hrvatski, pdf (208 KB) str. 61-65 preuzimanja: 1.029* citiraj
APA 6th Edition
ZAH BOGOVIĆ, T., TONKOVIĆ, D., SEKULIĆ, A., BANDIĆ-PAVLOVIĆ, D., BARONICA, R., BOGOVIĆ, M., ... TOMAŠEVIĆ, B.T. (2012). PATOFIZIOLOGIJA DELIRIJA. Acta medica Croatica, 66 (1), 61-65. Preuzeto s https://hrcak.srce.hr/93245
MLA 8th Edition
ZAH BOGOVIĆ, TAJANA, et al. "PATOFIZIOLOGIJA DELIRIJA." Acta medica Croatica, vol. 66, br. 1, 2012, str. 61-65. https://hrcak.srce.hr/93245. Citirano 22.10.2019.
Chicago 17th Edition
ZAH BOGOVIĆ, TAJANA, DINKO TONKOVIĆ, ANTE SEKULIĆ, DANIELA BANDIĆ-PAVLOVIĆ, ROBERT BARONICA, MARKO BOGOVIĆ, SANJA SAKAN, INA FILIPOVIĆ GRČIĆ i BORIS TOMAŠEVIĆ TOMAŠEVIĆ. "PATOFIZIOLOGIJA DELIRIJA." Acta medica Croatica 66, br. 1 (2012): 61-65. https://hrcak.srce.hr/93245
Harvard
ZAH BOGOVIĆ, T., et al. (2012). 'PATOFIZIOLOGIJA DELIRIJA', Acta medica Croatica, 66(1), str. 61-65. Preuzeto s: https://hrcak.srce.hr/93245 (Datum pristupa: 22.10.2019.)
Vancouver
ZAH BOGOVIĆ T, TONKOVIĆ D, SEKULIĆ A, BANDIĆ-PAVLOVIĆ D, BARONICA R, BOGOVIĆ M i sur. PATOFIZIOLOGIJA DELIRIJA. Acta medica Croatica [Internet]. 2012 [pristupljeno 22.10.2019.];66(1):61-65. Dostupno na: https://hrcak.srce.hr/93245
IEEE
T. ZAH BOGOVIĆ, et al., "PATOFIZIOLOGIJA DELIRIJA", Acta medica Croatica, vol.66, br. 1, str. 61-65, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/93245. [Citirano: 22.10.2019.]

Sažetak
Today’s understanding of the pathophysiological mechanisms of delirium is still limited, but there are several promising hypotheses. It is believed that biomarkers sensitive to death of neurons or glial cells indicate delirium. Several neurotransmitters are considered to be involved in the state of delirium, with greatest emphasis on acetylcholine and dopamine acting in opposite ways; acetylcholine reduces, while dopamine increases neuron excitability. Other neurotransmitters that probably play a role in the pathogenesis of delirium are GABA, glutamate and monoamines. Sepsis leading to systemic inflammatory response syndrome often presents with delirium and perhaps is the most common causal factor for delirium in intensive care unit; sedatives and analgesics are also common iatrogenic risk factors. Patients receiving benzodiazepines are more likely to have postoperative delirium than those who do not. Postoperative cognitive changes are more common in older than in younger patients, and they can be categorized as postoperative delirium, postoperative cognitive dysfunction and dementia. The mechanisms responsible for postoperative cognitive changes are not fully understood, but it is certain that they are multifactorial. Risk factors may be associated with patient characteristics, type of surgery and type of anesthesia.

Ključne riječi
delirium; intensive care unit; postoperative cognitive dysfunction; anesthesia; surgery; risk factors

Hrčak ID: 93245

URI
https://hrcak.srce.hr/93245

[hrvatski]

Posjeta: 1.702 *