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Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System

Ž. Davosir Klaric ; Croatian Agency for Medicinal Products and Medical Devices
A. Hafner ; Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb
S. Zubcic ; Croatian Agency for Medicinal Products and Medical Devices
M. Durrigl ; PharmaS Ltd., Zagreb, Croatia
J. Filipovic-Grcic ; Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Zagreb, Croatia

Puni tekst: engleski, pdf (585 KB) str. 355-364 preuzimanja: 449* citiraj
APA 6th Edition
Davosir Klaric, Ž., Hafner, A., Zubcic, S., Durrigl, M. i Filipovic-Grcic, J. (2012). Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System. Chemical and Biochemical Engineering Quarterly, 26 (4), 355-364. Preuzeto s https://hrcak.srce.hr/93992
MLA 8th Edition
Davosir Klaric, Ž., et al. "Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System." Chemical and Biochemical Engineering Quarterly, vol. 26, br. 4, 2012, str. 355-364. https://hrcak.srce.hr/93992. Citirano 28.07.2021.
Chicago 17th Edition
Davosir Klaric, Ž., A. Hafner, S. Zubcic, M. Durrigl i J. Filipovic-Grcic. "Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System." Chemical and Biochemical Engineering Quarterly 26, br. 4 (2012): 355-364. https://hrcak.srce.hr/93992
Harvard
Davosir Klaric, Ž., et al. (2012). 'Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System', Chemical and Biochemical Engineering Quarterly, 26(4), str. 355-364. Preuzeto s: https://hrcak.srce.hr/93992 (Datum pristupa: 28.07.2021.)
Vancouver
Davosir Klaric Ž, Hafner A, Zubcic S, Durrigl M, Filipovic-Grcic J. Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System. Chemical and Biochemical Engineering Quarterly [Internet]. 2012 [pristupljeno 28.07.2021.];26(4):355-364. Dostupno na: https://hrcak.srce.hr/93992
IEEE
Ž. Davosir Klaric, A. Hafner, S. Zubcic, M. Durrigl i J. Filipovic-Grcic, "Spray-driedMicrospheres Based on Chitosan and LecithinCyclosporin A Delivery System", Chemical and Biochemical Engineering Quarterly, vol.26, br. 4, str. 355-364, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/93992. [Citirano: 28.07.2021.]

Sažetak
Conventional and composed cyclosporin A (CsA)-loaded polymeric microspheres (MS) were prepared by spray-drying of CsA/chitosan one-phase system (solutions) and CsA/lecithin/chitosan two-phase system (suspensions). Microspheres were characterised in terms of production yield, entrapment efficiency, size distribution, zeta-potential, thermal properties, swelling ability and drug release profile. Conventional MS were characterised by mean diameter ranging from 1.15 ± 0.91 to 1.27 ± 0.84 m and CsA entrapment efficiency varying from 72.6 to 87.3%. Composed MS were characterised by larger mean diameter (1.32 ± 1.08 to 1.53 ± 1.15 m) and higher CsA entrapment efficiency (86.6–94.3%) compared to the corresponding conventional MS. Only composed MS showed swelling ability, which was proportional to chitosan base content in the preparation. In vitro CsA release profile depended on both,
the type of the spray-dried system and the chitosan used, as these factors were crucial in determining CsA entrapment pattern and swelling/dissolution ability of MS.

Ključne riječi
Chitosan; lecithin; microspheres; nanoparticles; cyclosporin; spray-drying; ocular delivery

Hrčak ID: 93992

URI
https://hrcak.srce.hr/93992

Posjeta: 693 *