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Collegium antropologicum, Vol.36 No.4 Prosinac 2012.

Izvorni znanstveni članak

The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients

Lea Duvnjak ; University of Zagreb, »Merkur« University Hospital, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia
Visnja Kokic ; University of Split, Split University Hospital Centre, Clinic for Internal Medicine, Clinical Department for Endocrinology, Diabetes and Metabilic Disease, Split, Croatia
Tomislav Bulum ; University of Zagreb, »Merkur« University Hospital, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia
Slaven Kokic ; University of Split, Split University Hospital Centre, Clinic for Internal Medicine, Clinical Department for Endocrinology, Diabetes and Metabilic Disease, Split, Croatia
Mladen Krnic ; University of Split, Split University Hospital Centre, Clinic for Internal Medicine, Clinical Department for Endocrinology, Diabetes and Metabilic Disease, Split, Croatia
Izet Salih Hozo ; University of Split, Split University Hospital Centre, Clinical Department for Gastroenterology and Hepatology, Split, Croatia

Puni tekst: engleski, pdf (172 KB) str. 1373-1378 preuzimanja: 250* citiraj
APA 6th Edition
Duvnjak, L., Kokic, V., Bulum, T., Kokic, S., Krnic, M. i Hozo, I.S. (2012). The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients. Collegium antropologicum, 36 (4), 1373-1378. Preuzeto s https://hrcak.srce.hr/94959
MLA 8th Edition
Duvnjak, Lea, et al. "The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients." Collegium antropologicum, vol. 36, br. 4, 2012, str. 1373-1378. https://hrcak.srce.hr/94959. Citirano 23.10.2018.
Chicago 17th Edition
Duvnjak, Lea, Visnja Kokic, Tomislav Bulum, Slaven Kokic, Mladen Krnic i Izet Salih Hozo. "The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients." Collegium antropologicum 36, br. 4 (2012): 1373-1378. https://hrcak.srce.hr/94959
Harvard
Duvnjak, L., et al. (2012). 'The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients', Collegium antropologicum, 36(4), str. 1373-1378. Preuzeto s: https://hrcak.srce.hr/94959 (Datum pristupa: 23.10.2018.)
Vancouver
Duvnjak L, Kokic V, Bulum T, Kokic S, Krnic M, Hozo IS. The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients. Collegium antropologicum [Internet]. 27.12.2012. [pristupljeno 23.10.2018.];36(4):1373-1378. Dostupno na: https://hrcak.srce.hr/94959
IEEE
L. Duvnjak, V. Kokic, T. Bulum, S. Kokic, M. Krnic i I.S. Hozo, "The Metabolic Syndrome is Associated With High-normal Urinary Albumin Excretion and Retinopathy in Normoalbuminuric Type 1 Diabetic Patients", Collegium antropologicum, vol.36, br. 4, str. 1373-1378, prosinac 2012. [Online]. Dostupno na: https://hrcak.srce.hr/94959. [Citirano: 23.10.2018.]

Sažetak
Although metabolic syndrome was not extensively studied in type 1 diabetes, higher insulin resistance, the core feature of the syndrome was found to be associated with increased risk of developing microvascular complications. As diabetic nephropathy may progress to advanced lesion before microalbuminuria appears, we investigated the association of the metabolic syndrome and estimated glucose disposal rate (eGDR) with urinary albumin excretion (UAE), retinopathy and neuropathy in normoalbuminuric type 1 diabetic patients. Two hundred and 98 patients (UAE <30 mg / 24 h at three occasions) were divided according to the IDF metabolic syndrome; eGDR (mg kg–1 min–1) was calculated: 24.31– (12.22 ´ WHR) – (3.29 ´ HT) – (0.57 ´ HbA1c), (WHR=waist-to-hip ratio, HT=hypertension). Patients with (n=99) compared to those without metabolic syndrome (N=199) showed higher UAE (15.96±9.10; 13.48±8.36 mg / 24 h), C-reactive protein (2.39±4.09;1.12±2.03 mg/L), prevalence of retinopathy (70.7;55.27%) and polyneuropathy (80.8; 68.3%), and lower eGDR (5.75±1.74; 8.96±1.9), (p>0.05). In patients with high-normal UAE, retinopathy and polyneuropathy eGDR was significantly lower compared with patients with low-normal UAE, and without retinopathy and polyneuropathy. In multiple regression analysis UAE and retinopathy were associated with diabetes duration (b= –0.20, b= -0.62), eGDR (b= – 0.106; b= –0.041), metabolic syndrome (b=0.49, b=0.28), (p>0.05). In type 1 diabetic patients insulin resistance and IDF defined metabolic syndrome are associated with high-normal UAE, retinopathy and polyneuropathy. The predictive value of the metabolic syndrome for development of microalbuminuria and retinopathy needs to be assessed in further follow-up studies.

Ključne riječi
metabolic syndrome; diabetes type 1; microvascular complications; urinary albumin excretion; retinopathy

Hrčak ID: 94959

URI
https://hrcak.srce.hr/94959

Posjeta: 424 *