Biochemia Medica, Vol. 23 No. 1, 2013.
Pregledni rad
https://doi.org/10.11613/BM.2013.007
Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts
Janja Zupan
; University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Ljubljana, Slovenia
Matjaž Jeras
; University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Ljubljana, Slovenia 2Celica, Biomedical Centre, Ljubljana, Slovenia
Janja Marc
orcid.org/0000-0001-6013-9758
; Celica, Biomedical Centre, Ljubljana, Slovenia
Sažetak
Bone and immune system are functionally interconnected. Immune and bone cells derive from same progenitors in the bone marrow, they share a common microenvironment and are being influenced by similar mediators. The evidence on increased bone resorption associated with inappropriate activation of T cells such as during inflammation, is well established. However, the molecular mechanisms beyond this clinical observation have begun to be intensively studied with the advancement of osteoimmunology. Now days, we have firm evidence on the influence of numerous pro-inflammatory cytokines on bone cells, with the majority of data focused on osteoclasts, the bone resorbing cells. It has been shown that some pro-inflammatory cytokines could possess osteoclastogenic and/or anti-osteoclastogenic properties and can target osteoclasts directly or via receptor activator of nuclear factor κB (RANK)/RANK ligand(RANKL)/osteoprotegerin (OPG) system. Several studies have reported opposing data regarding (anti)osteoclastogenic properties of these cytokines.
Therefore, the first part of this review is summarizing current evidence on the influence of pro-inflammatory cytokines on osteoclasts and thus on bone resorption. In the second part, the evidence on the role of pro-inflammatory cytokines in osteoporosis and osteoarthritis is reviewed to show that unravelling the mechanisms beyond such complex bone diseases, is almost impossible without considering skeletal and immune systems as an indivisible integrated system.
Ključne riječi
osteoimmunology; cytokines; osteoclasts; RANKL; osteoporosis
Hrčak ID:
97138
URI
Datum izdavanja:
15.2.2013.
Posjeta: 1.671 *