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Kratko priopćenje
https://doi.org/10.2478/acph-2013-0017

Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

RYM LAHSINI ; Laboratoire de Chimie Analytique et d’Electrochimie, Université de Carthage, Institut National des Sciences Appliquées et de Technologie, 1080 Tunis Cedex, Tunisia
MOHAMED R. LOUHAICHI ; Laboratoire National de Contrôle des Médicaments, 1006 Tunis, Tunisia
NAFAA ADHOUM ; Laboratoire de Chimie Analytique et d’Electrochimie, Université de Carthage, Institut National des Sciences Appliquées et de Technologie, 1080 Tunis Cedex, Tunisia
LOTFI MONSER ; Laboratoire de Chimie Analytique et d’Electrochimie, Université de Carthage, Institut National des Sciences Appliquées et de Technologie, 1080 Tunis Cedex, Tunisia

Puni tekst: engleski, pdf (172 KB) str. 265-275 preuzimanja: 1.119* citiraj
APA 6th Edition
LAHSINI, R., LOUHAICHI, M.R., ADHOUM, N. i MONSER, L. (2013). Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues. Acta Pharmaceutica, 63 (2), 265-275. https://doi.org/10.2478/acph-2013-0017
MLA 8th Edition
LAHSINI, RYM, et al. "Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues." Acta Pharmaceutica, vol. 63, br. 2, 2013, str. 265-275. https://doi.org/10.2478/acph-2013-0017. Citirano 20.08.2019.
Chicago 17th Edition
LAHSINI, RYM, MOHAMED R. LOUHAICHI, NAFAA ADHOUM i LOTFI MONSER. "Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues." Acta Pharmaceutica 63, br. 2 (2013): 265-275. https://doi.org/10.2478/acph-2013-0017
Harvard
LAHSINI, R., et al. (2013). 'Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues', Acta Pharmaceutica, 63(2), str. 265-275. https://doi.org/10.2478/acph-2013-0017
Vancouver
LAHSINI R, LOUHAICHI MR, ADHOUM N, MONSER L. Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues. Acta Pharm. [Internet]. 2013 [pristupljeno 20.08.2019.];63(2):265-275. https://doi.org/10.2478/acph-2013-0017
IEEE
R. LAHSINI, M.R. LOUHAICHI, N. ADHOUM i L. MONSER, "Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues", Acta Pharmaceutica, vol.63, br. 2, str. 265-275, 2013. [Online]. https://doi.org/10.2478/acph-2013-0017

Sažetak
The performance of a molecularly imprinted polymer (MIP) as selective packing material for solid-phase extraction (SPE) of residual glibenclamide in an industrial process was investigated. MIP was prepared using 4-vinylpyridine as monomer, ethylenedimethacrylate as cross linker, 2,2’-azobis-2-methylpropionitrile as initiator and dimethyl formamide as porogen. Use of acetonitrile as a rebinding solvent allows good recognition of the glibenclamide template. It was found that this polymer can be used for determination of trace levels of glibenclamide with a recovery percentage that could reach 87.1 %. Furthermore, the synthesized MIP showed higher selectivity towards glibenclamide than other compounds such as glimepiride and metformine. The synthesized MIP enabled direct determination of the target contaminant after an enrichment step that allowed quantification of a low glibenclamide concentration as low as 0.016 mg L–1. Combination of high performance liquid chromatography with MIP-SPE could be successfully used for quality control of pharmaceuticals during the cleaning process in the production of dry drug forms.

Ključne riječi
glibenclamide; molecular imprinted polymer; solid phase extraction; HPLC

Hrčak ID: 97703

URI
https://hrcak.srce.hr/97703

Posjeta: 1.399 *