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https://doi.org/10.2478/acph-2013-0012

Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry

DINESH S. PATEL ; Chemistry Department, Pramukh Swami Science and H.D. Patel Arts College, Sarva Vidyalaya Campus, Kadi-382 715, Gujarat, India; Bio-Analytical Laboratory, Cliantha Research Ltd., Bodakdev, Ahmedabad-380054, Gujarat, India
NAVEEN SHARMA ; Bio-Analytical Laboratory, Cliantha Research Ltd., Bodakdev, Ahmedabad-380054, Gujarat, India
MUKESH C. PATEL ; 1 Chemistry Department, Pramukh Swami Science and H.D. Patel Arts College, Sarva Vidyalaya Campus, Kadi-382 715, Gujarat, India
BHAVIN N. PATEL ; Bio-Analytical Laboratory, Cliantha Research Ltd., Bodakdev, Ahmedabad-380054, Gujarat, India; Department of Chemistry, School of Sciences, Gujarat University, Navrangpura, Ahmedabad-380009, Gujarat, India
PRANAV S. SHRIVASTAV ; Department of Chemistry, School of Sciences, Gujarat University, Navrangpura, Ahmedabad-380009, Gujarat, India
MALLIKA SANYAL ; Department of Chemistry, St. Xavier’s College, Navrangpura, Ahmedabad-380009, Gujarat, India

Puni tekst: engleski, pdf (348 KB) str. 141-158 preuzimanja: 1.436* citiraj
APA 6th Edition
PATEL, D.S., SHARMA, N., PATEL, M.C., PATEL, B.N., SHRIVASTAV, P.S. i SANYAL, M. (2013). Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry. Acta Pharmaceutica, 63 (2), 141-158. https://doi.org/10.2478/acph-2013-0012
MLA 8th Edition
PATEL, DINESH S., et al. "Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry." Acta Pharmaceutica, vol. 63, br. 2, 2013, str. 141-158. https://doi.org/10.2478/acph-2013-0012. Citirano 20.10.2019.
Chicago 17th Edition
PATEL, DINESH S., NAVEEN SHARMA, MUKESH C. PATEL, BHAVIN N. PATEL, PRANAV S. SHRIVASTAV i MALLIKA SANYAL. "Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry." Acta Pharmaceutica 63, br. 2 (2013): 141-158. https://doi.org/10.2478/acph-2013-0012
Harvard
PATEL, D.S., et al. (2013). 'Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry', Acta Pharmaceutica, 63(2), str. 141-158. https://doi.org/10.2478/acph-2013-0012
Vancouver
PATEL DS, SHARMA N, PATEL MC, PATEL BN, SHRIVASTAV PS, SANYAL M. Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry. Acta Pharm. [Internet]. 2013 [pristupljeno 20.10.2019.];63(2):141-158. https://doi.org/10.2478/acph-2013-0012
IEEE
D.S. PATEL, N. SHARMA, M.C. PATEL, B.N. PATEL, P.S. SHRIVASTAV i M. SANYAL, "Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry", Acta Pharmaceutica, vol.63, br. 2, str. 141-158, 2013. [Online]. https://doi.org/10.2478/acph-2013-0012

Sažetak
A reliable, selective and sensitive LC-MS/MS assay has been proposed for the determination of nitrofurantoin in human plasma. The analyte and nitrofurazone were extracted from 100 µL of human plasma via SPE on Strata-X 33 µm extraction cartridges. Chromatography was done on a BDS Hypersil C18 (100 mm × 4.6 mm, 5 µm) column under isocratic conditions. Quantitation was done using the multiple reaction monitoring (MRM) mode for deprotonated precursor to product ion transitions of nitrofurantoin (m/z 237.0 → 151.8) and nitrofurazone (m/z 197.0 →123.9). The limit of detection and the lowest limit of quantitation of the method were 0.25 ng mL–1 and 5.00 ng mL–1, respectively, with a linear dynamic range of 5.00–1500 ng mL–1 for nitrofurantoin. The intra-batch and inter-batch precision (RSD, %) was ≤ 5.8 %, while the mean extraction recovery was > 92 %. The method was successfully applied to a bioequivalence study of a 100 mg nitrofurantoin capsule formulation in 36 healthy subjects.

Ključne riječi
nitrofurantoin; LC-MS/MS; solid phase extraction; human plasma; bioequivalence; incurred sample reanalysis

Hrčak ID: 97694

URI
https://hrcak.srce.hr/97694

Posjeta: 1.664 *