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Acta Pharmaceutica, Vol. 63 No. 2, 2013.

Kratko priopćenje
https://doi.org/10.2478/acph-2013-0013

Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization

RAMESH JAKKI ; Nanotechnology Laboratory, Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh-506009, India
MUZAMMIL AFZAL SYED ; Nanotechnology Laboratory, Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh-506009, India
PRABHAKAR KANDADI ; Nanotechnology Laboratory, Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh-506009, India
KISHAN VEERABRAHMA ; Nanotechnology Laboratory, Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh-506009, India

Puni tekst: engleski, pdf (129 KB) str. 241-251 preuzimanja: 819* citiraj
APA 6th Edition
JAKKI, R., SYED, M.A., KANDADI, P. i VEERABRAHMA, K. (2013). Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization. Acta Pharmaceutica, 63 (2), 241-251. https://doi.org/10.2478/acph-2013-0013
MLA 8th Edition
JAKKI, RAMESH, et al. "Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization." Acta Pharmaceutica, vol. 63, br. 2, 2013, str. 241-251. https://doi.org/10.2478/acph-2013-0013. Citirano 18.02.2019.
Chicago 17th Edition
JAKKI, RAMESH, MUZAMMIL AFZAL SYED, PRABHAKAR KANDADI i KISHAN VEERABRAHMA. "Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization." Acta Pharmaceutica 63, br. 2 (2013): 241-251. https://doi.org/10.2478/acph-2013-0013
Harvard
JAKKI, R., et al. (2013). 'Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization', Acta Pharmaceutica, 63(2), str. 241-251. doi: https://doi.org/10.2478/acph-2013-0013
Vancouver
JAKKI R, SYED MA, KANDADI P, VEERABRAHMA K. Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization. Acta Pharm. [Internet]. 2013 [pristupljeno 18.02.2019.];63(2):241-251. doi: https://doi.org/10.2478/acph-2013-0013
IEEE
R. JAKKI, M.A. SYED, P. KANDADI i K. VEERABRAHMA, "Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization", Acta Pharmaceutica, vol.63, br. 2, str. 241-251, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0013

Sažetak
The main objective of this work was to prepare a self-micro emulsifying drug delivery system (SMEDDS) for enhancement of oral bioavailability of domperidone, a poorly water soluble drug. The solubility of the drug was determined in various vehicles. A pseudo ternary phase diagram was constructed to identify the self-micro emulsification region. The in vitro self-micro emulsification properties and droplet size of SMEDDS were studied following their addition to water under mild agitation. Further, the resultant formulations were investigated for clarity, phase separation, globule size, effect of pH and dilutions (1:100, 1:500, 1:1000). The optimized formulation, SMEDDS-B used for in vitro dissolution and bioavailability assessment, contained oil (Labrafac CC, 25 %, m/m), surfactant (Tween 80, 55 %, m/m), and co-surfactant (Transcutol®, 20 %, m/m). The preliminary oral bioavailability of domperidone from SMEDDS was 1.92-fold higher compared to that of domperidone suspension in rats. The AUC0-24 and cmax values were 3.38 ± 0.81 µg h mL–1 and 0.44 ± 0.03 µg mL–1 for SMEDDS-B formulation in comparison with 1.74 ± 0.18 µg h mL–1 and 0.24 ± 0.02 µg mL-1 for domperidone suspension suggesting a significant increase (p < 0.05) in oral bioavailability of domperidone from SMEDDS.

Ključne riječi
domperidone; SMEDDS; lipophilic drug delivery; particle size; enhanced oral bioavailability

Hrčak ID: 97701

URI
https://hrcak.srce.hr/97701

Posjeta: 975 *